Natural killer group 2D receptor and its ligands in cancer immune escape

Molecular Cancer
Shixin DuanFuyan Wang

Abstract

The immune system plays important roles in tumor development. According to the immune-editing theory, immune escape is the key to tumor survival, and exploring the mechanisms of tumor immune escape can provide a new basis for the treatment of tumors. In this review, we describe the mechanisms of natural killer group 2D (NKG2D) receptor and NKG2D ligand (NKG2DL) in tumor immune responses.Natural killer (NK) cells are important cytotoxic cells in the immune system, and the activated NKG2D receptor on the NK cell surface can bind to NKG2DL expressed in tumor cells, enabling NK cells to activate and kill tumor cells. However, tumors can escape the immune clearance mediated by NKG2D receptor/NKG2DL through various mechanisms. The expression of NKG2D receptor on NK cells can be regulated by cells, molecules, and hypoxia in the tumor microenvironment. Tumor cells regulate the expression of NKG2DL at the level of transcription, translation, and post-translation and thereby escape recognition by NK cells. In particular, viruses and hormones have special mechanisms to affect the expression of NKG2D receptor and NKG2DL. Therefore, NKG2D\NKG2DL may have applications as targets for more effective antitumor therapy.

References

Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helmut R SalihAlexander Steinle
Nov 12, 2002·Nature Immunology·Susan GilfillanMarco Colonna
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jack D BuiRobert D Schreiber
Jun 6, 2006·Biochemical and Biophysical Research Communications·N Jan ChalupnyDavid Cosman
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth A SzliterLinda D Hazlett
Sep 4, 2007·Trends in Endocrinology and Metabolism : TEM·Michelle A CareyDarryl C Zeldin
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mathias KrockenbergerJörg Wischhusen
Aug 5, 2008·Nature Immunology·Noam Stern-GinossarOfer Mandelboim
Oct 7, 2008·Oncogene·I Waldhauer, A Steinle
Jan 3, 2009·Cellular & Molecular Immunology·Chaoyang WenHui Zhong
Dec 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas LundqvistRichard Childs
Dec 15, 2010·Cell Biology International·Dahui SunYan Zhang
May 20, 2011·RNA Biology·Yoav Bauman, Ofer Mandelboim
Jul 15, 2011·Nature·Andrea FacciabeneGeorge Coukos
Dec 16, 2011·The Journal of Biological Chemistry·Da LinChristopher A O'Callaghan
Jan 5, 2012·Cancer Immunology, Immunotherapy : CII·Leticia Huergo-ZapicoSegundo Gonzalez
Jun 26, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia HilpertHelmut Rainer Salih
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eric T ClambeyHolger K Eltzschig
Nov 28, 2012·Science·Noam Stern-GinossarJonathan S Weissman
Feb 12, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giulia MatusaliMargherita Doria
Jan 1, 2012·BoneKEy Reports·Jeroen T BuijsTheresa A Guise

❮ Previous
Next ❯

Citations

May 3, 2019·Cancer Science·Chun-Mei FanZhao-Yang Zeng
Apr 20, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dan WangCan Guo
May 5, 2020·Molecular Oncology·Ting TangZhaoyang Zeng
Mar 13, 2020·International Journal of Cancer. Journal International Du Cancer·Sarun JuengpanichXiujun Cai
Aug 25, 2019·Molecular Cancer·Miao PengZhaoyang Zeng
Oct 1, 2020·Journal of Experimental & Clinical Cancer Research : CR·Xianjie JiangWei Xiong
Mar 11, 2020·Frontiers in Immunology·Anja KlussmeierVinzenz Lange
Aug 9, 2020·Molecular Cancer·Song-Yang WuZhi-Ming Shao
Aug 6, 2020·Cancers·S Elizabeth FranksJames W Hodge
Jul 13, 2020·Cellular and Molecular Life Sciences : CMLS·Fang WeiZhaoyang Zeng
Apr 21, 2020·Cancer Immunology, Immunotherapy : CII·Alessandra ZeccaGabriele Missale
Aug 11, 2020·Mediators of Inflammation·Yingying ChenRong Fu
Aug 23, 2020·International Journal of Molecular Sciences·Augusto BleveFrancesca Maria Consonni
Oct 8, 2020·International Journal of Molecular Sciences·Magdalena HuberMatthias Lauth
Nov 5, 2019·Molecular Cancer Research : MCR·Tshering D Lama-Sherpa, Lalita A Shevde
Dec 29, 2020·Translational Oncology·Hui MengLiang Wang
Feb 11, 2021·Personalized Medicine·Gholamreza FarnooshMohammad-Reza Mahmoudian-Sani
Dec 10, 2020·International Journal of Molecular Sciences·Abdul Q KhanShahab Uddin
Jan 10, 2021·Cancers·Yang ZhangJing Wang
Jan 29, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhenhui WuYingjian Zeng
Nov 20, 2020·Cancers·Julien Schaller, Judith Agudo
Jan 19, 2021·Clinical & Translational Immunology·Luke RigganTimothy E O'Sullivan
Mar 3, 2021·Journal of Experimental & Clinical Cancer Research : CR·Yijie ZhangWei Xiong
May 1, 2021·Journal of Experimental & Clinical Cancer Research : CR·Fenghua TanCan Guo
Apr 21, 2021·Seminars in Cell & Developmental Biology·Deepti SinghHifzur R Siddique
May 13, 2021·Journal of Experimental & Clinical Cancer Research : CR·Lvyuan LiCan Guo
Jun 4, 2021·Journal of Hepatocellular Carcinoma·Alessandro GranitoFrancesco Tovoli
Jun 12, 2021·Frontiers in Neuroscience·Luke MaggsSoldano Ferrone
Jul 14, 2021·BMC Immunology·Young Shin LeeJaeho Bae

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleotide exchange
acetylation
antisense oligonucleotides

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.