Natural Killer Lymphocytes Are Dysfunctional in Kidney Transplant Recipients on Diagnosis of Cancer

Transplantation
Marie-Noëlle PeraldiAntoine Toubert

Abstract

The incidence of cancer is increased after solid organ transplantation. Natural killer (NK) cells are key effectors of the tumor immune response. We conducted a cross sectional multicentre matched case-control study including 42 kidney transplant recipients (KTRs) on diagnosis of cancer and 41 KTRs without cancer. Extensive phenotyping of NK cells populations and functional tests of NK cells were performed. Kidney transplant recipients with cancer had a higher incidence of acute rejection (P = 0.02) and cytomegalovirus (CMV) infection (P = 0.03) than controls. They had more lymphopenia than control KTRs (1020/mm3 +/- 32 vs 1218/mm3 +/- 34; P = 0.001) including a CD4+ lymphopenia (P = 0.01). Total CD3-/CD56+ NK cell counts were similar in both groups. However, KTRs with cancer had a lower frequency of the cytokine-enriched CD56bright NK cell subset (P = 0.001). The percentage of NK cells expressing NKp46 was decreased in KTRs with cancer (45% vs 53 %, P = 0.001). Furthermore, the ability of NK cells to degranulate CD107a+ cytolytic vesicles was reduced (11% vs 22%; P = 0.02), and the percentage of NK cells secreting IFN[gamma] was decreased (7.5% vs 28.8%; P = 0.01) in KTRs with cancer. These results reveal an imbalance between ...Continue Reading

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Citations

Sep 20, 2017·Transplantation·Akinbami Adenugba
May 29, 2018·Nature Reviews. Nephrology·Eric AuJeremy R Chapman
May 26, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G WongW H Lim
Aug 15, 2020·Frontiers in Immunology·Paola PontrelliGiovanni Stallone
Mar 13, 2021·Seminars in Cancer Biology·Rupen DesaiGavin P Dunn
May 1, 2021·Cancers·Cecilia Nakid-CorderoVincent Vieillard
Feb 24, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Cecilia Nakid-CorderoUNKNOWN K-VIROGREF Study Group

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