Natural killer (NK) activity and interferon (IFN) production by a fraction of spleen and blood lymphocytes in swine.

Veterinary Immunology and Immunopathology
H SalmonA Paraf

Abstract

After carbonyl iron treatment and gradient isolation, spleen and blood pig lymphocytes exhibited NK activity and produced IFN after viral induction. Removal of plastic-adherent cells, including the majority of B cells, did not change these activities. The plastic-non-adherent cells were further separated into two subsets of roughly similar size by panning using a monoclonal, anti-T, and anti-null cell antibodies (81 + cells). NK activity and IFN production were found in the 81 - cell fraction. A significantly higher proportion of null lymphocytes from blood and of splenic Fc-gamma receptor-bearing lymphocytes was also found among the 81 - cell fraction as compared to the 81 + fraction, without any change among other subsets. Similar proportions of helper (PT4+), cytotoxic (PT8+) and total T cells (MSA4+) were found among lymphocytes bound to target K562 cells and among the whole lymphocyte population. In contrast, lymphocytes that bound K562 cells demonstrated a striking increase in the proportion of Fc-gamma receptor-positive cells of high affinity. These results show that NK cells and IFN-producing cells are mainly included in the same blood and spleen fraction, and suggest that among 81 - cells only those expressing an Fc-ga...Continue Reading

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Citations

Jan 1, 1993·Veterinary Research Communications·D L Evans, L Jaso-Friedmann
Aug 1, 1991·Veterinary Immunology and Immunopathology·M BüttnerB Obermann
Mar 1, 1992·Veterinary Microbiology·D Naidoo, J B Derbyshire
Jan 22, 1998·Veterinary Immunology and Immunopathology·S De GuiseM Fournier
Dec 30, 1999·Veterinary Immunology and Immunopathology·H Salmon
Jul 14, 2005·Immunology·Johanna de GrootCornelis G van Reenen
Oct 8, 2013·Veterinary Immunology and Immunopathology·Estelle RousseletCéline A J Godard-Codding

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