PMID: 6977553Jul 1, 1981Paper

Natural killing and antibody-dependent cytotoxicity by lymphocyte subpopulations in young and aging humans

Journal of Clinical Immunology
G Fernandes, S Gupta

Abstract

Natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) were examined in the peripheral blood lymphocytes and their major subpopulations from young and aging subjects. Monocyte-depleted unseparated lymphocyte-mediated NK activity (against cells of K-562) and ADCC (against IgG-coated chicken erythrocytes) were comparable between young and aging subjects. Similarly no significant difference was observed in T cell-mediated NK and ADCC and non-T cell-mediated ADCC between young and aging subjects. Non-T cell-mediated NK activity, however, was significantly (P less than 0.025) greater in aging humans compared to that of young subjects. When the data were analyzed according to gender, T cell-mediated ADCC in aging males was significantly (P less than 0.05) greater than that found in young males. No significant difference was observed between T-cell ADCC among young and aging females. T cell-mediated NK was comparable among young and aging males and young and aging females. Non-T cell-mediated NK as well as ADCC activity was significantly (P[ less than 0.025 or less than 0.05) greater in aging males compared to that in young males. Both non-T-cell NK and ADCC were comparable among young and aging females. This study de...Continue Reading

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