PMID: 6984221Dec 1, 1982Paper

Natural killing and antibody-dependent cytotoxicity by T leukaemic blasts from acute lymphoblastic leukaemia

Scandinavian Journal of Immunology
S Gupta, G Fernandes

Abstract

Bone marrow T leukaemic blasts from four patients with T-cell acute lymphoblastic leukaemia (ALL) were examined as effectors in natural killing (NK) and antibody-dependent cytotoxicity (ADCC). T leukaemic blasts demonstrated both Nk (against K-562 cells as targets) and ADCC (against chicken erythrocytes (CRBC) and cells of SB cell line as targets). NK activity and ADCC (against SB cells) were comparable to NK and ADCC (against SB cells) of peripheral blood T cells from healthy controls. ADCC against CRBC by leukaemic blasts was lower than that of peripheral T cells from normal controls. Of leukaemic blasts 20-42% possessed IgG Fc receptors. This study demonstrates that T leukaemic blasts are effectors in NK and ADCC assays.

References

Jan 1, 1978·Contemporary Topics in Immunobiology·R Kiessling, O Haller
Jan 1, 1978·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·D CatovskyM Cherchi
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R A DeFronzoP Felig
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Jan 1, 1978·Advances in Cancer Research·R B Herberman, H T Holden

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