Natural melanoma-derived extracellular vesicles

Seminars in Cancer Biology
Joshua L Hood

Abstract

Melanoma cells produce a variety of extracellular vesicle (EV) types including shedding vesicles and exosomes (EXOs). These EVs are defined by their mechanism of cellular production. To date, the majority of EV investigations has centered around melanoma EXOs or small EVs (sEVs). Natural melanoma sEVs mediate pro-tumor processes including angiogenesis, immune regulation and modification of tissue microenvironments. A thorough examination of these processes reveals that they are interdependent. They work in concert to support tumor growth and survival. Pro-tumor functions attributed to melanoma cells are reproduced by melanoma sEVs. This ensures a certain degree of redundancy within the melanoma pathogenic process. It also allows for rapid adaptation of melanoma cells to changing microenvironments, anti-tumor immune responses, and therapeutic challenges. Further, as a result of their composition and inherent ability to engage the immune system, natural melanoma EVs possess excellent biomarker potential and might be used therapeutically as tumor vaccines.

References

Jan 1, 1995·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·S Krüger-KrasagakesT Diamantstein
Aug 22, 2000·The Journal of Investigative Dermatology·U B HofmannD J Ruiter
Jun 28, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Steven A StackerMarc G Achen
Jul 31, 2002·Lancet·Fabrice AndreLaurence Zitvogel
Nov 7, 2003·Human Immunology·Béatrice RiteauNathalie Rouas-Freiss
Apr 6, 2007·Cancer Research·Roberta ValentiLicia Rivoltini
Dec 11, 2007·Cancer Metastasis Reviews·François-Clément BidardMarie-France Poupon
Dec 18, 2007·Seminars in Oncology·Ganapati H Mahabeleshwar, Tatiana V Byzova
Jan 30, 2008·Current Protocols in Cell Biology·Clotilde ThéryAled Clayton
Apr 1, 2008·Breast Cancer Research : BCR·Joanne E BluffCarolyn A Staton
May 16, 2008·Journal of Cellular Physiology·Matthias Rinderknecht, Michael Detmar
Jul 23, 2008·Experimental Dermatology·Dan Ilkovitch, Diana M Lopez
Dec 6, 2008·Journal of Cell Science·Christina WasmeierMiguel C Seabra
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Khalid Al-NedawiJanusz Rak
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Federica FelicettiAlessandra Carè
Aug 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva U WieckowskiTheresa L Whiteside
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raj S KasthuriNigel Mackman
Sep 30, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Joshua L HoodUNKNOWN Consortium for Translational Research in Advanced Imaging and Nanomedicine (C-TRAIN)
Oct 6, 2009·The Journal of Biological Chemistry·Isabella ParoliniStefano Fais
Aug 31, 2010·The American Journal of Pathology·Xiaoyu XiangHuang-Ge Zhang
Jan 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taoyong ChenXuetao Cao
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Robert R Langley, Isaiah J Fidler
Apr 6, 2011·Experimental & Molecular Medicine·Yeong Shin LeeChul Woo Kim
Apr 12, 2011·Cancer Research·Joshua L HoodSamuel A Wickline
Jan 21, 2012·Blood·Willem Stoorvogel
Feb 22, 2012·Seminars in Cancer Biology·Viktor Umansky, Alexandra Sevko
Jun 1, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Joshua L Hood, Samuel A Wickline
Aug 18, 2012·Immunology Letters·Annamaria MartonKrisztina Buzas
Oct 12, 2012·PloS One·Deyi XiaoKelly M McMasters
Jun 19, 2013·Molecular Cancer·Germana RappaAurelio Lorico
Jun 19, 2013·Biological Chemistry·Fatemeh Momen-HeraviWinston Patrick Kuo

❮ Previous
Next ❯

Citations

Apr 17, 2020·Cancers·Magali BoyerCatherine Alix-Panabières
Dec 10, 2020·International Journal of Molecular Sciences·Abdul Q KhanShahab Uddin
Jan 29, 2021·Cytotechnology·Najla Adel SalehTânia Beatriz Creczynski-Pasa
Apr 20, 2021·Cancer Metastasis Reviews·Hendrik Hld VandyckVéronique Winnepenninckx

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved