Natural menstrual rhythm and oral contraception diversely affect exhaled breath compositions

Scientific Reports
Pritam SukulWolfram Miekisch

Abstract

Natural menstrual cycle and/or oral contraception diversely affect women metabolites. Longitudinal metabolic profiling under constant experimental conditions is thereby realistic to understand such effects. Thus, we investigated volatile organic compounds (VOCs) exhalation throughout menstrual cycles in 24 young and healthy women with- and without oral contraception. Exhaled VOCs were identified and quantified in trace concentrations via high-resolution real-time mass-spectrometry, starting from a menstruation and then repeated follow-up with six intervals including the next bleeding. Repeated measurements within biologically comparable groups were employed under optimized measurement setup. We observed pronounced and substance specific changes in exhaled VOC concentrations throughout all cycles with low intra-individual variations. Certain blood-borne volatiles changed significantly during follicular and luteal phases. Most prominent changes in endogenous VOCs were observed at the ovulation phase with respect to initial menstruation. Here, the absolute median abundances of alveolar ammonia, acetone, isoprene and dimethyl sulphide changed significantly (P-value ≤ 0.005) by 18.22↓, 13.41↓, 18.02↑ and 9.40↓%, respectively. These ...Continue Reading

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Citations

Jul 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jorge A M PereiraJosé S Câmara
Sep 22, 2020·Journal of Breath Research·Karsten KönigsteinAndreas T Güntner
Jan 3, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ting ChenQianming Chen
Mar 12, 2021·Critical Reviews in Analytical Chemistry·Maryam KhoubnasabjafariAbolghasem Jouyban
Mar 25, 2021·Journal of Breath Research·Natalia DrabińskaBen De Lacy Costello
Oct 9, 2019·Chemical Reviews·Tobias BrudererRenato Zenobi

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Methods Mentioned

BETA
contraception

Software Mentioned

Breath tracker
SigmaPlot
MATLAB

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