Interest in D-amino acids has increased in recent decades with the development of new analytical methods highlighting their presence in all kingdoms of life. Their involvement in physiological functions, and the presence of metabolic routes for their synthesis and degradation have been shown. Furthermore, D-amino acids are gaining considerable importance in the pharmaceutical industry. The immense amount of information scattered throughout the literature makes it difficult to achieve a general overview of their applications. This review summarizes the state-of-the-art on D-amino acid applications and occurrence, providing both established and neophyte researchers with a comprehensive introduction to this topic.
beta-lactam antibiotics. II. Structure-activity relationships of 6-[alpha-(alpha'-ureido-acylamino) acylamino] penicillanic acids
Studies on mycobacillin derivatives. IV. O-methylation of the antibiotic and identification of the active tyrosine residue
Laboratory studies with cefatrizine (SK + F 60771), a new broad-spectrum orally-active cephalosporin
Opioid activity of dermenkephalin analogues in the guinea-pig myenteric plexus and the hamster vas deferens
Isolation of achatin-I, a neuroactive tetrapeptide having a D-phenylalanine residue, from Achatina ganglia, and its effects on Achatina giant neurones
Hydrophobicity of beta-lactam antibiotics. Explanation and prediction of their behaviour in various partitioning solvent systems and reversed-phase chromatography
Somatostatin analogs as adjuncts to agonists of luteinizing hormone-releasing hormone in the treatment of experimental prostate cancer
D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons
Beta-lactam antibiotics. I. Comparative structure--activity relationships of 6-acylaminopenicillanic acid derivatives and their 6-(D-alpha-acylaminophenylacetamido) penicillanic acid analogues
Second FEBS-Ferdinand Springer lecture: Membrane active complexones. Chemistry and biological function
In vitro antibacterial activity of SM-1652, a new broad-spectrum cephalosporin with antipseudomonal activity
A novel D-amino acid-containing peptide, fulyal, coexists with fulicin gene-related peptides in Achatina atria
Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library.
The effect of gramicidin, a topical contraceptive and antimicrobial agent with anti-HIV activity, against herpes simplex viruses type 1 and 2 in vitro
Characterization of the genes encoding D-amino acid transaminase and glutamate racemase, two D-glutamate biosynthetic enzymes of Bacillus sphaericus ATCC 10208
Simple high-performance liquid chromatography determination of ampicillin in human serum using solid-phase extraction disk cartridges
Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production
L to D amino acid isomerization in a peptide hormone is a late post-translational event occurring in specialized neurosecretory cells
Proliferative processes in the epidermis of patients with atopic dermatitis treated with thymodepressin
Antimicrobial activity and stability to proteolysis of small linear cationic peptides with D-amino acid substitutions
Establishment of hepatic stem-like cell lines from normal adult porcine liver in a poly-D-lysine-coated dish with NAIR-1 medium
Partial D-amino acid substitution: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide
A randomly coiled, high-molecular-weight polypeptide exhibits increased paracellular diffusion in vitro and in situ relative to the highly ordered alpha-helix conformer
Esterification of Escherichia coli tRNAs with D-histidine and D-lysine by aminoacyl-tRNA synthetases
D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties
Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily
Intrinsic asymmetries of amino acid enantiomers and their peptides: a possible role in the origin of biochirality
Treatment for low-risk gestational trophoblastic disease: comparison of single-agent methotrexate, dactinomycin and combination regimens
D-amino acids in the brain: structure and function of pyridoxal phosphate-dependent amino acid racemases
Evaluation of D-18F-FMT, 18F-FDG, L-11C-MET, and 18F-FLT for monitoring the response of tumors to radiotherapy in mice
Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography
What is most important is what comes across : Urological guidelines from the target group's point of view
Distribution and stable isotopic composition of amino acids from fungal peptaibiotics: assessing the potential for meteoritic contamination
Racemization in reverse: evidence that D-amino acid toxicity on Earth is controlled by bacteria with racemases
Enantiomeric purity determination of (L)-amino acids with pre-column derivatization and chiral stationary phase: development and validation of the method
Structural basis for an atypical active site of an l-aspartate/glutamate-specific racemase from Escherichia coli
Green chemistry approaches to leather tanning process for making chrome-free leather by unnatural amino acids
Highly stereoselective recognition and deracemization of amino acids by supramolecular self-assembly
Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic
Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study
Cloning, expression and characterization of D-aminoacylase from Achromobacter xylosoxidans subsp. denitrificans ATCC 15173
Cloning, heterologous expression, and characterization of the gene cluster required for gougerotin biosynthesis
Efficient synthesis of D-branched-chain amino acids and their labeled compounds with stable isotopes using D-amino acid dehydrogenase
The stereoselectivity and hydrolysis efficiency of recombinant D-hydantoinase from Vigna angularis Against 5-benzylhydantoin derivatives with halogen and methyl substituents
The Case for Extant Life on Mars and Its Possible Detection by the Viking Labeled Release Experiment
Structural insights into the substrate recognition and reaction specificity of the PLP-dependent fold-type I isoleucine 2-epimerase from Lactobacillus buchneri
Activation of Recombinantly Expressed l-Amino Acid Oxidase from Rhizoctonia solani by Sodium Dodecyl Sulfate
Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site
Efficient production of poly γ-d-glutamic acid from the bloom-forming green macroalgae, Ulva sp., by Bacillus sp. SJ-10
Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
Identification and functional characterization of NAD(P)+ -dependent meso-diaminopimelate dehydrogenase from Numidum massiliense
Through the looking glass: Chiral recognition of substrates and products at the active sites of racemases and epimerases
Peptidomimetics - An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules.
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Evolution of Pluripotency
Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.
Lipidomics & Rhinovirus Infection
Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.
Alzheimer's Disease: MS4A
Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.
Generating Insulin-Secreting Cells
Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.
Central Pontine Myelinolysis
Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.
Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.