Natural occurrence of left-handed (Z) regions in PM2 DNA

Journal of Biomolecular Structure & Dynamics
F D MillerJ B Rattner

Abstract

Bacteriophage PM2 DNA, a ccc genome of high apparent superhelical density, contains left-handed (Z) regions as detected by competitive radioimmunoassay, agarose gel electrophoresis of DNA: antibody complexes and immunoelectron microscopy. The latter technique, in conjunction with partial blockage of restriction endonuclease sites by bound antibody, was used to map the left-handed regions along the DNA molecule. A cluster of four to five antibody molecules (approximately 25% of bound antibody) was located within map units 0.05-0.18 of the single Hpa II restriction site. Sequence analysis of part of this region showed the presence of several areas of high alternating purine-pyrimidine content. A strong correlation is observed between alternating pyrimidine-purine tracts of significant length and antibody binding sites.

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Citations

Oct 1, 1983·Journal of Biomolecular Structure & Dynamics·T M JovinF Eckstein
Dec 1, 1983·Journal of Biomolecular Structure & Dynamics·B RevetA Niveleau
Jan 1, 1989·International Reviews of Immunology·B D Stollar
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