Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Vivitri PrasastyEnade Istyastono

Abstract

Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer's disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management.

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Citations

Feb 26, 2020·Environmental Science and Pollution Research International·Sondes MechriBassem Jaouadi
Oct 28, 2019·Data in Brief·Vivitri Dewi Prasasty, Enade Perdana Istyastono
Jul 21, 2020·Journal of Chemical Information and Modeling·Enade P IstyastonoSudi Mungkasi

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Methods Mentioned

BETA
column chromatography
gel-filtration
Thin-layer
gel
ion exchange chromatography

Software Mentioned

Biopep
NAMD

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