Natural Polymer-Based Antimicrobial Hydrogels without Synthetic Antibiotics as Wound Dressings.

Biomacromolecules
Yajie ZhongYongcan Jin

Abstract

Wound healing is usually accompanied by bacterial infection. The excessive use of synthetic antibiotics leads to drug resistance, posing a significant threat to human health. Hydrogel-based wound dressings aimed at mitigating bacterial infections have emerged as an effective wound treatment. The review presented herein particularly focuses on the hydrogels originating from natural polymers. To further enhance the performance of wound dressings, various strategies and approaches have been developed to endow the hydrogels with excellent broad-spectrum antibacterial activity. Those that are summarized in the current review are the hydrogels with intrinsic or stimuli-triggered bactericidal properties and others that serve as vehicles for loading antibacterial agents without synthetic antibiotics. Specific attention is paid to antimicrobial mechanisms and the antibacterial performance of hydrogels. Practical antibacterial applications to accelerate the wound healing employing these antibiotic-free hydrogels are also introduced along with the discussion on the current challenges and perspectives leading to new technologies.

References

Jan 1, 1997·Trends in Microbiology·R E Hancock
Nov 11, 2003·Biomacromolecules·Entsar I RabeaWalter Steurbaut
Nov 13, 2003·Bioorganic & Medicinal Chemistry Letters·S KhabnadidehA A Farrokhroz
Mar 17, 2004·Current Opinion in Infectious Diseases·Ruth Edwards, Keith G Harding
Feb 11, 2005·Nature Reviews. Microbiology·Kim A Brogden
Jan 19, 2006·Clinical Microbiology Reviews·C F CarsonT V Riley
May 16, 2006·Trends in Pharmacological Sciences·Tai-Ping FanRicky N S Wong
Feb 23, 2007·Nature·Sheila MacNeil
Mar 1, 2009·Microbial Biotechnology·Dina Raafat, Hans-Georg Sahl
Jan 26, 2011·Biotechnology Advances·R JayakumarH Tamura
Apr 4, 2012·Antioxidants & Redox Signaling·Katarzyna A Broniowska, Neil Hogg
Aug 31, 2013·Chemical Communications : Chem Comm·Jie GaoQiang Zhao
Jan 18, 2014·Biomacromolecules·Nicholas P ReynoldsPatrick G Hartley
Mar 19, 2014·Biopolymers·Sayani Chattopadhyay, Ronald T Raines
Nov 22, 2014·Science·Bryan K SunPaul A Khavari
Dec 4, 2014·Food Chemistry·Sandrina A HelenoIsabel C F R Ferreira
Feb 5, 2015·Chemical Society Reviews·C Ghobril, M W Grinstaff
Feb 11, 2015·International Journal of Molecular Sciences·Yan XueYi Zhang
Mar 10, 2015·Journal of Advanced Research·Enas M Ahmed
May 29, 2015·Clinical Microbiology Reviews·Steven Y C TongVance G Fowler
Aug 27, 2015·ACS Nano·Melek KiristiJoseph Wang
Oct 11, 2015·Carbohydrate Polymers·Yuanfeng PanMeaghan Colpitts
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Dafu WeiHuining Xiao
Dec 22, 2015·Carbohydrate Polymers·Na PengChunyu Chang
Jan 19, 2016·International Journal of Biological Macromolecules·Mahmoud Hosseinnejad, Seid Mahdi Jafari
Jun 14, 2016·ACS Applied Materials & Interfaces·María Emilia VillanuevaGuillermo Javier Copello
Aug 31, 2016·Current Topics in Medicinal Chemistry·Deanna L ZubrisWilliam M Wuest
Oct 16, 2016·International Journal of Antimicrobial Agents·Dragica SpasojevićKsenija Radotić
Dec 13, 2016·International Journal of Biological Macromolecules·R RaguvaranAnju Manuja
Feb 17, 2017·Molecular Pharmaceutics·Jiaul HoqueJayanta Haldar
Feb 28, 2017·Journal of Advanced Research·Elbadawy A KamounXin Chen
Mar 11, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Yaoming WanZhibo Li
Apr 17, 2017·International Journal of Biological Macromolecules·Ijaz BanoMuhammad Younus
Apr 20, 2017·Biomacromolecules·Ivaylo StefanovTzanko Tzanov

❮ Previous
Next ❯

Citations

Mar 3, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wen ShiBin Duan
Apr 30, 2021·Carbohydrate Polymers·Hadi RastinDusan Losic
Jul 21, 2021·ACS Applied Materials & Interfaces·Huize LuoXingyu Jiang
Jul 2, 2021·ACS Biomaterials Science & Engineering·Reza GharibiSeema Agarwal
Aug 11, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brinta BhattacharjeeJayanta Haldar
Aug 29, 2021·Advanced Healthcare Materials·Huan LeiDaidi Fan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.