Natural Polymorphisms Are Present in the Furin Cleavage Site of the SARS-CoV-2 Spike Glycoprotein

Frontiers in Genetics
Yue XingQunfeng Dong

Abstract

The furin cleavage site in the spike glycoprotein of the SARS-CoV-2 coronavirus is considered important for the virus to enter the host cells. By analyzing 45828 SARS-CoV-2 genome sequences, we identified 103 strains of SARS-CoV-2 with various DNA mutations including 18 unique non-synonymous point mutations, one deletion, and six gains of premature stop codon that may affect the furin cleavage site. Our results revealed that the furin cleavage site might not be required for SARS-CoV-2 to enter human cells in vivo. The identified mutants may represent a new subgroup of SARS-CoV-2 coronavirus with reduced tropism and transmissibility as potential live-attenuated vaccine candidates.

References

Jun 10, 2010·Nature Biotechnology·Adam S LauringRaul Andino
Aug 26, 2011·Protein Expression and Purification·Ann M TothDonald L Jarvis
Apr 7, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Yuelong Shu, John McCauley
May 12, 2018·Bioinformatics·Heng Li
Jan 10, 2017·Global Challenges·Stefan Elbe, Gemma Buckland-Merrett
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Mar 21, 2020·Current Biology : CB·Tao ZhangZhigang Zhang
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
May 27, 2020·ELife·Praveen AnandVenky Soundararajan
Jul 17, 2020·Frontiers in Microbiology·Yue XingQunfeng Dong

❮ Previous
Next ❯

Citations

Dec 20, 2020·Stem Cell Research·Yiran Wu, Suwen Zhao
Dec 29, 2020·Frontiers in Immunology·Gisela Canedo-MarroquínAlexis M Kalergis
Mar 9, 2021·Frontiers in Medicine·Christian A DevauxDidier Raoult
Apr 4, 2021·Animals : an Open Access Journal From MDPI·John T HancockAlexander Greenhough
Jul 7, 2021·Translational Medicine Communications·Gerald Dieter Griffin
Aug 4, 2021·Journal of Medicinal Chemistry·Essam Eldin A OsmanNouri Neamati
Aug 3, 2021·Infection·Ahmed M AlmehdiSameh S M Soliman

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-Seq

Software Mentioned

MicoGMT
Ada
minimap2
snpEff
microbial genomics mutation tracker ( MicroGMT )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.