PMID: 8947607Nov 1, 1996Paper

Natural polyreactive IgA and IgM autoantibodies in human colostrum

Scandinavian Journal of Immunology
Tchavdar L Vassilev, K V Veleva

Abstract

Secretory antibodies against bacteria and viruses in human colostrum and milk are known to be important protective factors for the breast-fed infant. The authors have shown by enzyme immunoassay that colostrum contains IgA and IgM antibodies to a number of autoantigens: native DNA, actin, myosin, myoglobin, laminin, transferrin and thyroglobulin. These antibodies were polyspecific-those with anti-DNA reactivity immunopurified on a DNA-cellulose affinity column bound to a panel of self- and environmental antigens. The levels of natural autoantibodies in the immunoglobulin fraction of human colostrum were 3-10 times lower (when presented as antibody activity per microgram of immunoglobulin) than in the immunoglobulin fraction of serum. The biological significance of the presence of B cells with autoantibody specificity in the mammary gland and of natural autoantibodies in colostrum and milk is not clear. It has been suggested that self-reacting autoantibodies in serum play a major role in the selection of the pre-immune B-cell repertoire and in the maintenance of the immune homeostasis. The authors hypothesize that the natural autoantibodies in colostrum and milk may contribute to the selection process of physiological repertoire...Continue Reading

Citations

Jul 11, 2012·Journal of Clinical Immunology·Jaroslava PribylovaHelena Tlaskalova-Hogenova
Jul 11, 2003·Progress in Retinal and Eye Research·Bob MeekRon Peek
Dec 4, 2003·The Lancet Infectious Diseases·Athena P KourtisAnn Duerr
May 19, 2006·Journal of Pediatric Gastroenterology and Nutrition·María Teresa AsensiJavier Buesa
Feb 10, 2011·Journal of Translational Medicine·Lucia Lopalco
Feb 9, 2000·Bioscience, Biotechnology, and Biochemistry·M ShimodaC Kanno
Nov 16, 2010·Future Microbiology·Anitra D Thomas, William Parker
Aug 3, 2014·Veterinary Parasitology·Hayley M ToetR Mark Sandeman
Sep 29, 2011·Preventive Veterinary Medicine·A T M van KnegselH K Parmentier
Oct 9, 2007·Advances in Pediatrics·Armond S GoldmanDavid K Rassin
Aug 9, 2016·Veterinary Immunology and Immunopathology·N MayasariH K Parmentier
Aug 14, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Iglika Djoumerska-AlexievaAndrey Tchorbanov
Apr 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asaf MadiIrun R Cohen
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hicham BouhlalHakim Hocini

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