Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Evidence-based Complementary and Alternative Medicine : ECAM
Nur Shafika Mohd Sairazi, K N S Sirajudeen

Abstract

In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

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Citations

Jul 22, 2020·Journal of Food Biochemistry·Alam Zeb
Aug 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Htoo Tint SanKittisak Likhitwitayawuid
Nov 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana SilvaRui Pedrosa
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Oct 8, 2021·Environmental Science and Pollution Research International·Rahul TripathiPravir Kumar

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