Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview

Frontiers in Microbiology
Kesava Rao V KurapatiMadhavan P N Nair

Abstract

As the threat of Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) persists to rise, effective drug treatments are required to treat the infected people. Even though combination antiretroviral therapy (cART) provides stable viral suppression, it is not devoid of undesirable side effects, especially in persons undergoing long-term treatment. The present therapy finds its limitations in the emergence of multidrug resistance and accordingly finding new drugs and novel targets is the need of the hour to treat the infected persons and further to attack HIV reservoirs in the body like brain, lymph nodes to achieve the ultimate goal of complete eradication of HIV and AIDS. Natural products such as plant-originated compounds and plant extracts have enormous potential to become drug leads with anti-HIV and neuroprotective activity. Accordingly, many research groups are exploring the biodiversity of the plant kingdom to find new and better anti-HIV drugs with novel mechanisms of action and for HIV-associated neurocognitive disorders (HAND). The basic challenge that still persists is to develop viral replication-targeted therapy using novel anti-HIV compounds with new mode of action, accepted toxicity and less r...Continue Reading

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Citations

Oct 18, 2016·Frontiers in Immunology·Céline MarbanChristian Schwartz
May 15, 2018·International Journal of Molecular Sciences·Bahare SalehiJavad Sharifi-Rad
Dec 29, 2017·Journal of Asian Natural Products Research·Jia-Mei GuoYing Guo
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ramandeep KaurDinesh Kumar
Mar 26, 2019·Plant Biotechnology Journal·Peyman HabibiMaria Fatima Grossi-de-Sa
Dec 21, 2019·Phytotherapy Research : PTR·Marcella DenaroDomenico Trombetta
Nov 13, 2020·Frontiers in Plant Science·Anamika PandeySait Gezgin
Jul 3, 2021·International Journal of Molecular Sciences·Ali MovahediQiang Zhuge
Aug 14, 2020·Chemical Research in Toxicology·Clarissa FeltrinCláudia Maria Oliveira Simões
Feb 7, 2020·Current Drug Discovery Technologies·Ahsan JavedMehdi Pasalar

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