Natural Products as Modulators of Sirtuins.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Berin Karaman MayackFidele Ntie-Kang

Abstract

Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources there has been a decline in financial support and efforts in characterization of natural products. Advances in the design of chemical compounds and the understanding of their functions is of pharmacological importance for the biomedical field. However, natural products regained attention as sources of novel drug candidates upon recent developments and progress in technology. Natural compounds were shown to bear an inherent ability to bind to biomacromolecules and cover an unparalleled chemical space in comparison to most libraries used for high-throughput screening. Thus, natural products hold a great potential for the drug discovery of new scaffolds for therapeutic targets such as sirtuins. Sirtuins are Class III histone deacetylases that have been linked to many diseases such as Parkinson`s disease, Alzheimer's disease, type II diabetes, and cancer linked to aging. In this review, we examine the revitalization of interest in natural products for drug discovery and discuss nat...Continue Reading

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Citations

Jan 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wolfgang Sippl, Fidele Ntie-Kang
Feb 19, 2021·Frontiers in Pharmacology·Ramu ManjulaFrancisco J Alcain
Mar 23, 2021·Frontiers in Pharmacology·Fidele Ntie-KangCecilia Battistelli
Jun 3, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alberto ZulloWerner Klingler
May 25, 2021·British Journal of Pharmacology·Jefferson A LeiteNiels O S Câmara

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Methods Mentioned

BETA
Nuclear Magnetic Resonance
NMR
X-ray
deacylation
ELISA
in

Software Mentioned

GB
LigandScout
MM

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