Natural products as promising targets in glioblastoma multiforme: a focus on NF-κB signaling pathway

Pharmacological Reports : PR
Mohammad SoukhtanlooAmir R Afshari

Abstract

Glioblastoma multiforme (GBM), as the broadest cerebrum tumor, is resistant to current medical interventions, particularly chemo/radiation. Hence, it necessitates further therapeutic options that could enhance the efficacy of existing modalities. A comprehensive and systematic review of literature on the NF-κB signaling pathway-contributed in the pathogenesis of GBM with a focus on natural products was carried out. Several examinations have shown that nuclear factor (NF)-κB is participated in apoptosis, cellular proliferation, angiogenesis, metastasis, invasion, and many other processes implicated in GBM pathobiology. Recent studies have provided that NF-κB regulation is the primary pharmacological target for GBM therapy. Specific natural products are involved in several signaling pathways implicated in tumor growth and apoptosis of GBM cells. In the current review, we elaborate on the role of NF-κB as a promising target in GBM and discuss some natural products affecting the NF-κB signaling pathway.

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Citations

May 27, 2020·Oxidative Medicine and Cellular Longevity·Mohammad Jalili-NikAmirhossein Sahebkar
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Luciana Fentanes Moura de MeloKatia Castanho Scortecci
May 15, 2021·Oxidative Medicine and Cellular Longevity·Maria Lúcia da Silva CordeiroKatia Castanho Scortecci
Jul 16, 2020·Current Drug Metabolism·Elmira MohtashamiAmir R Afshari
Aug 10, 2020·Mini Reviews in Medicinal Chemistry·Amir R AfshariAmirhossein Sahebkar

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