Natural Products as Sources of New Drugs from 1981 to 2014

Journal of Natural Products
David Newman, Gordon M Cragg

Abstract

This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all approved therapeutic agents, the time frame has been extended to cover the 34 years from January 1, 1981, to December 31, 2014, for all diseases worldwide, and from 1950 (earliest so far identified) to December 2014 for all approved antitumor drugs worldwide. As mentioned in the 2012 review, we have continued to utilize our secondary subdivision of a "natural product mimic", or "NM", to join the original primary divisions and the designation "natural product botanical", or "NB", to cover those botanical "defined mixtures" now recognized as drug entities by the U.S. FDA (and similar organizations). From the data presented in this review, the utilization of natural products and/or their novel structures, in order to discover and develop the final drug entity, is still alive and well. For example, in the area of cancer, over the time frame from around the 1940s to the end of 2014, of the 175 small molecules approved, 131, or 75%, are other than "S" (synthetic), with 85, or 49%, actually being either natural products or directly derived therefrom. In...Continue Reading

References

Apr 20, 1967·Biochemical and Biophysical Research Communications·I Schechter, A Berger
Jan 1, 1967·Helvetica Chimica Acta·R HütterH Zähner
Jun 1, 1996·Bioscience, Biotechnology, and Biochemistry·J KohnoK Kawashima
Jan 1, 1997·Journal of Natural Products·Gordon M CraggKenneth M Snader
Sep 16, 1998·Current Opinion in Chemical Biology·A S Ripka, D H Rich
Aug 23, 2002·Pharmacology & Therapeutics·Doriano FabbroPaul W Manley
Jul 26, 2003·Journal of Natural Products·David NewmanKenneth M Snader
Aug 21, 2003·Biochemical and Biophysical Research Communications·Jeanette M WoodMartin P Bedigian
Sep 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Christian ThorkildsenJørgen Søberg Petersen
Dec 25, 2003·Angewandte Chemie·Martin D Burke, Stuart L Schreiber
Jun 9, 2005·Current Opinion in Chemical Biology·Ayub Reayi, Prabhat Arya
Apr 4, 2006·Drug Discovery Today·Ricardo Macarron
Jul 4, 2006·Current Opinion in Chemical Biology·Thomas H KellerZheng Yin
Feb 21, 2007·Journal of Natural Products·David Newman, Gordon M Cragg
Jun 20, 2007·Nature Chemical Biology·Thomas J Maimone, Phil S Baran
Feb 12, 2009·Drug News & Perspectives·Ann I GraulRosa Castañer
Feb 16, 2010·Drug News & Perspectives·Ann I GraulLaura Revel
Apr 23, 2010·Current Opinion in Chemical Biology·Sivaraman Dandapani, Lisa A Marcaurelle
Aug 25, 2010·Journal of Medicinal Chemistry·Randy L WebbJürgen Maibaum
Dec 3, 2010·Expert Opinion on Investigational Drugs·Stephen M Ansell
Jan 25, 2011·Bioorganic & Medicinal Chemistry·Kevin K-C LiuJin Li
Mar 2, 2011·Nature Reviews. Drug Discovery·Ricardo MacarronG Sitta Sittampalam
Mar 5, 2011·Drugs of Today·Ann I Graul, E Cruces
Jan 21, 2012·Bioorganic & Medicinal Chemistry·Kevin K-C LiuHong X Ding
Feb 10, 2012·Journal of Natural Products·David Newman, Gordon M Cragg
Mar 3, 2012·Drugs of Today·Ann I GraulM Stringer
Mar 24, 2012·Molecular Oncology·Swen HoelderPaul Workman
Dec 19, 2012·Nature Chemistry·Björn OverHerbert Waldmann
Feb 23, 2013·Biochimica Et Biophysica Acta·Gordon M Cragg, David Newman
Apr 12, 2013·Natural Product Reports·Kyung Bo Kim, Craig M Crews
Apr 30, 2013·Bioorganic & Medicinal Chemistry·Hong X DingChristopher J O'Donnell
May 10, 2013·ACS Synthetic Biology·Maulik N Thaker, Gerard D Wright
Jun 25, 2013·Clinical Lymphoma, Myeloma & Leukemia·Hagop M KantarjianJorge Cortes
Oct 22, 2013·Natural Product Reports·Armin Bauer, Mark Brönstrup
Dec 18, 2013·Natural Product Reports·Christian A KuttruffPhil S Baran
Jan 11, 2014·Nature Biotechnology·Michael HayJesse Rosenthal
Jan 25, 2014·Journal of Natural Products·Tamam El-ElimatNicholas H Oberlies

Citations

Mar 16, 2016·Pharmaceutical Research·Irlan Almeida Freires, Pedro Luiz Rosalen
Mar 25, 2016·Chemical & Pharmaceutical Bulletin·Kengo MasudaMasayuki Inoue
Apr 15, 2016·Current Opinion in Microbiology·Hans-Peter Grossart, Keilor Rojas-Jimenez
Jun 6, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yang-Yang HanJin-Ming Gao
Jun 28, 2016·European Journal of Medicinal Chemistry·Ye DingJia Zhou
Jun 2, 2016·ACS Chemical Biology·Caitlin D DeaneDouglas A Mitchell
Jun 29, 2016·Journal of the American Chemical Society·Veronica TonaNuno Maulide
Jul 20, 2016·BMC Complementary and Alternative Medicine·Tahira YounisNaseer Ali Shah
Jul 20, 2016·The Journal of Organic Chemistry·Claire M Gober, Madeleine M Joullié
Aug 6, 2016·Trends in Microbiology·Paul R Jensen
Aug 4, 2016·Future Medicinal Chemistry·Mariana González-MedinaJosé L Medina-Franco
Aug 16, 2016·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Aug 11, 2016·Journal of Medical Virology·Ying-Shan HanMark A Wainberg
Jul 28, 2016·Current Opinion in Biotechnology·Ryo Nakabayashi, Kazuki Saito
Aug 24, 2016·PloS One·Maria Lund NielsenThomas Ostenfeld Larsen
Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dahong LiJinyi Xu
Sep 14, 2016·PloS One·Scott B VafaiVamsi K Mootha
Sep 18, 2016·Current Opinion in Chemical Biology·Clarissa Melo CzeksterJames H Naismith
Sep 7, 2016·Organic Letters·Jun Huang, Zhang Wang
Sep 27, 2016·Nature Chemical Biology·Kunhua LiSteven D Bruner
Oct 1, 2016·Biochemical Pharmacology·Takuji NakashimaSatoshi Ōmura
Sep 24, 2016·Analytical Chemistry·Jakub PřichystalVladimír Havlíček
Nov 3, 2016·Oxidative Medicine and Cellular Longevity·Jaqueline Ferreira CamposEdson Lucas Dos Santos
Oct 1, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kaiqing MaXuemei Qin
Oct 18, 2016·Nature Chemical Biology·John ChuSean F Brady
Oct 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael A SkinniderNathan A Magarvey
Nov 9, 2016·Frontiers in Pharmacology·Shivankar AgrawalSunil K Deshmukh
Nov 9, 2016·European Journal of Medicinal Chemistry·Guanqun ZhanGuangmin Yao
Nov 1, 2016·Journal of Agricultural and Food Chemistry·Yuhui Bi, Zhiguo Yu
Nov 10, 2016·Marine Drugs·Bálint GálNoah Z Burns
Nov 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong-Jie ZhangDjaja Doel Soejarto
Nov 1, 2016·Journal of the American Chemical Society·Tucker MaxsonDouglas A Mitchell

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

© 2021 Meta ULC. All rights reserved