Natural products for the treatment of trachoma and Chlamydia trachomatis

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Michael G Potroz, Nam-Joon Cho

Abstract

The neglected tropical disease (NTD) trachoma is currently the leading cause of eye disease in the world, and the pathogenic bacteria causing this condition, Chlamydia trachomatis, is also the most common sexually transmitted pathogenic bacterium. Although the serovars of this bacterial species typically vary between ocular and genital infections there is a clear connection between genital C. trachomatis infections and the development of trachoma in infants, such that the solutions to these infections are closely related. It is the unique life cycle of the C. trachomatis bacteria which primarily leads to chronic infections and challenges in treatment using conventional antibiotics. This life cycle involves stages of infective elementary bodies (EBs) and reproductive reticulate bodies (RBs). Most antibiotics only target the reproductive RBs and this often leads to the need for prolonged therapy which facilitates the development of drug resistant pathogens. It is through combining several compounds to obtain multiple antimicrobial mechanisms that we are most likely to develop a reliable means to address all these issues. Traditional and ethnobotanical medicine provides valuable resources for the development of novel formulations ...Continue Reading

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Citations

Aug 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angélique LewiesDu Plessis Lissinda Hester
Oct 19, 2016·Microorganisms·Mika A BrownNam-Joon Cho
Feb 17, 2021·Veterinary Medicine and Science·Sawsan M A El-SheikhAzza A A Galal
Aug 3, 2021·International Journal of Food Science·Rebecca NakazibaPaul E Alele
Sep 7, 2021·Journal of Biomolecular Structure & Dynamics·Jyoti RaniUrmi Bajpai
Sep 9, 2021·Clinical Microbiology Reviews·Oyelola AdegboyeClaire Loiseau

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Methods Mentioned

BETA
acylation
glycosylation
electron microscopy

Software Mentioned

BASANT

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