PMID: 16515528Mar 7, 2006Paper

Natural products from marine invertebrates and microbes as modulators of antitumor targets

Current Drug Targets
David J Newman, Gordon M Cragg

Abstract

Over the last twenty-five to thirty years, exploration of the marine fauna and microbial flora has progressed from a random search by natural product chemists who liked to dive and wished to combine their hobby with their profession, to fully integrated programs of systemic investigation of the chemical agents elaborated by marine organisms of all phyla (as presumably defensive agents against predators) for their potential as leads to human-use drug candidates where the putative mechanisms have been identified as modulation of, and/or interaction with, potential molecular targets, rather than just exhibiting general cytotoxicity. This review is not exhaustive but is meant to cover the highlights of such agents and is arranged on a (nominal) target basis rather than by organism or chemical class.

Citations

Jun 15, 2010·Marine Biotechnology·Nicole S WebsterElizabeth Evans-Illidge
Apr 5, 2008·Journal of Industrial Microbiology & Biotechnology·Michelle J SungaKin S Lam
May 18, 2013·Chemical Reviews·Sandip B BharateRam A Vishwakarma
Nov 23, 2007·Natural Product Reports·Dwight D BakerVineet Rajgarhia
Feb 6, 2008·Natural Product Reports·John W BluntMichèle R Prinsep
Apr 17, 2009·Anti-cancer Drugs·Daniel V LaBarberaChris M Ireland
May 24, 2013·Marine Drugs·Marta Pelay-GimenoFernando Albericio
Jul 4, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tim S BugniChris M Ireland
Feb 7, 2014·Journal of Natural Products·Gordon M CraggDavid J Newman
Dec 25, 2012·Trends in Biotechnology·Helena M AmaroF Xavier Malcata
Jun 17, 2008·Metabolism: Clinical and Experimental·Barbara SchmidtIlya Raskin
Apr 1, 2011·Biotechnology Progress·A Catarina GuedesF Xavier Malcata
Jun 15, 2007·Methods : a Companion to Methods in Enzymology·Walter C DunlapDavid J Newman
Jul 6, 2014·Organic Letters·Koji MizukiYoshihide Usami
May 20, 2014·Journal of Agricultural and Food Chemistry·Xingyun LiMin Huang
Nov 6, 2018·International Journal of Cancer. Journal International Du Cancer·Prasanta DeyHyung Sik Kim
Sep 1, 2009·Current Protocols in Pharmacology·John A Beutler
Mar 7, 2021·Marine Drugs·Qi-Ting ZhangYu-Fen Zhao
Feb 18, 2010·Current Protocols in Pharmacology·John A Beutler
May 16, 2008·Journal of the American Chemical Society·Abimael D RodríguezJames J La Clair
May 9, 2009·Chemical Reviews·Gordon M CraggDavid J Newman
Feb 14, 2007·Journal of the American Chemical Society·Belhu B MetaferiaCarole A Bewley
May 29, 2008·Journal of Natural Products·Tim S BugniChris M Ireland

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