Natural products, PGC-1 α , and Duchenne muscular dystrophy

Acta Pharmaceutica Sinica. B
Ipek SuntarSeyed Mohammad Nabavi

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) is a transcriptional coactivator that binds to a diverse range of transcription factors. PPARγ coactivator 1 (PGC-1) coactivators possess an extensive range of biological effects in different tissues, and play a key part in the regulation of the oxidative metabolism, consequently modulating the production of reactive oxygen species, autophagy, and mitochondrial biogenesis. Owing to these findings, a large body of studies, aiming to establish the role of PGC-1 in the neuromuscular system, has shown that PGC-1 could be a promising target for therapies targeting neuromuscular diseases. Among these, some evidence has shown that various signaling pathways linked to PGC-1α are deregulated in muscular dystrophy, leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species (ROS) production. In the light of these results, any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular dystrophies. PGC-1α is influenced by different patho-physiological/pharmacological stimuli. Natural products have been reported to display modulatory effects on PPARγ activation with fewer side effects in comp...Continue Reading

Citations

Apr 21, 2021·Reproductive Biology·Aynaz MihanfarMohammad Hassan Khadem-Ansari
Jun 8, 2021·Acta Pharmaceutica Sinica. B·Fen LongXinhua Liu
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Leila ChodariAziz Eftekhari
Aug 14, 2021·Acta Pharmaceutica Sinica. B·Anil AhsanXiangnan Zhang

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Methods Mentioned

BETA
antisense oligonucleotides
biopsies
antisense oligonucleotide

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