Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

Natural Product Reports
Hideaki Kakeya

Abstract

Covering: 1993 to 2016The exploitation of small molecules from natural sources, such as microbial metabolites, has contributed to the discovery of not only new drugs but also new research tools for chemical biology. My research team has discovered several novel bioactive small molecules using in vivo cell-based phenotypic screening, and has investigated their modes of action using chemical genetics and chemical genomics. This highlight focuses on our recent discoveries and chemical genetics approaches for bioactive microbial metabolites that target cancer cells, the cancer microenvironment and cell membrane signalling. In addition, the development of two new platforms, 5-sulfonyl tetrazole-based and thiourea-modified amphiphilic lipid-based probe technologies, to identify the cellular targets of these molecules is also discussed.

References

Jun 5, 1997·Nature·K Simons, E Ikonen
Dec 18, 2004·The Biochemical Journal·Yoko NagumoHiroyuki Osada
Mar 4, 2008·Microbiology·Tomoko IwakiKaoru Takegawa
Apr 11, 2008·Molecular Microbiology·Reinhard FischerNorio Takeshita
Mar 31, 2009·Nature Chemical Biology·Dong-Chan OhJon Clardy
Mar 31, 2009·Nature Chemical Biology·Shinya TsukijiItaru Hamachi
May 22, 2009·Nature·Rob PhillipsPierre Sens
Jun 15, 2010·Nature Chemical Biology·Shinichi NishimuraMinoru Yoshida
Aug 11, 2010·Journal of the American Chemical Society·Hyun Seung BanHiroyuki Nakamura
Nov 26, 2010·Applied and Environmental Microbiology·Hiroyasu OnakaTamotsu Furumai
Jun 28, 2011·Nature Reviews. Drug Discovery·David C Swinney, Jason Anthony
Nov 1, 2011·Current Opinion in Structural Biology·Joanne Oates, Anthony Watts
Nov 15, 2011·Structure·Unal Coskun, Kai Simons
Jan 31, 2012·Chemistry & Biology·Raymond E Moellering, Benjamin F Cravatt
Feb 10, 2012·Journal of Natural Products·David J Newman, Gordon M Cragg
Feb 12, 2013·Nature Methods·Jonathan J HulceBenjamin F Cravatt
Feb 19, 2013·Bioorganic & Medicinal Chemistry Letters·Satsuki OtsukiHideaki Kakeya
Aug 14, 2013·Annual Review of Pathology·Gregg L Semenza
Sep 13, 2013·Nature Reviews. Molecular Cell Biology·Helen Saibil
Jun 17, 2015·Biochimica Et Biophysica Acta·Gregg L Semenza
Jul 1, 2015·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Michio MurataNobuaki Matsumori

❮ Previous
Next ❯

Citations

Sep 13, 2018·Expert Opinion on Drug Discovery·Fisayo OlotuMahmoud Soliman
Sep 19, 2019·Chemical Communications : Chem Comm·Nobuaki TakahashiHideaki Kakeya
May 22, 2019·The Journal of Antibiotics·Ken-Ichi Kimura
Oct 9, 2020·Organic & Biomolecular Chemistry·Chengqian PanHideaki Kakeya
Mar 2, 2021·Journal of Natural Products·Kohei FujitaHideaki Kakeya
Mar 2, 2021·Chemical & Pharmaceutical Bulletin·Ryota MorimotoHideaki Kakeya
Feb 3, 2021·Chembiochem : a European Journal of Chemical Biology·Lobna A ElsadekHendrik Luesch
Aug 1, 2021·The Journal of Antibiotics·Hiroaki Ikeda, Hideaki Kakeya
Feb 19, 2020·The Journal of Organic Chemistry·Nobuaki TakahashiHideaki Kakeya
Sep 1, 2020·ACS Chemical Biology·Takefumi KuranagaHideaki Kakeya
Nov 17, 2021·The Journal of Organic Chemistry·Naoki KanohHideaki Kakeya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Chemical Biology
Terry RoemerCorey Nislow
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Luc Dirix
Nihon rinsho. Japanese journal of clinical medicine
Makoto Kawatani, Hiroyuki Osada
Current Topics in Medicinal Chemistry
Louise Cathrine Braun Olsen, Nils Joakim Færgeman
© 2022 Meta ULC. All rights reserved