Natural Reading in Parkinson's Disease With and Without Mild Cognitive Impairment

Frontiers in Aging Neuroscience
Lena StockJosefine Waldthaler

Abstract

Background: Patients with Parkinson's disease (PD) show eye movement abnormalities and frequently complain about difficulties in reading. So far, it is unclear whether basal ganglia dysfunction or cognitive impairment has a greater impact on eye movements during reading. Objective: To analyze eye movement behavior during a natural reading task with respect to cognitive state and dopaminergic therapy in PD and healthy controls. Methods: Eye movements of 59 PD patients and 29 age- and education-matched healthy controls were recorded during mute, self-paced reading of a text. 25 cognitively normal PD patients performed the task additionally in off medication state. Clinical assessment included a comprehensive neuropsychological test battery and the motor section of MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Results: PD-mild cognitive impairment (MCI) was diagnosed in 21 patients. Reading speed was significantly reduced in PD-MCI compared to healthy controls and PD patients without MCI due to higher numbers of progressive saccades. Cognitively intact PD patients showed no significant alterations of reading speed or eye movement pattern during reading. The fixation duration tended to be prolonged in PD compared to hea...Continue Reading

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Citations

Dec 30, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Jan RuszElina Tripoliti

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Methods Mentioned

BETA
MDS

Software Mentioned

R
OpenSesame
IReST
EyeLink 1000 PLUS
Demtect
eyelinker

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