PMID: 8589525Aug 1, 1995Paper

Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene

Mammalian Genome : Official Journal of the International Mammalian Genome Society
M C BeckersP Gros

Abstract

Legionella pneumophila is a strict intracellular pathogen that replicates in the professional phagocytes of the human and guinea pig host. Although murine macrophages from most inbred strains are non-permissive to intracellular replication of L. pneumophila, inflammatory macrophages from the mouse strain A/J are completely permissive to intracellular replication of this bacterium. This genetic difference is controlled by the expression of a single autosomal gene designated Lgn1, with non-permissiveness behaving as completely dominant over permissiveness. We have used a total of 25 AXB/BXA recombinant inbred mouse strains and 182 (A/J x C57BL/6J) x A/J segregating backcross progeny (A/J, permissive; C57BL/6J, non-permissive) to map the Lgn1 gene. Animals were individually typed for tolerance to intracellular replication by in vitro infection of their inflammatory macrophages with L. pneumophila. All animals segregated into two nonoverlapping groups. Examination of the strain distribution pattern of the AXB/BXA strains for Lgn1 initially identified linkage to Chromosome (Chr) 13 markers. Genotyping of the 25 AXB/BXA strains and the 182 backcross progeny for 11 Chr 13 markers established that Lgn1 mapped to Chr 13, with the gene o...Continue Reading

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Citations

Mar 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C J DiDonatoL R Simard
Jun 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C H YenR W Elliott
Sep 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E DiezP Gros
Jan 22, 2009·Apoptosis : an International Journal on Programmed Cell Death·Christian R McIntireMaya Saleh
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Aug 25, 2000·Genome Research·M G EndrizziW F Dietrich
Apr 9, 2010·Clinical Microbiology Reviews·Hayley J NewtonElizabeth L Hartland
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May 6, 2016·Frontiers in Microbiology·Kathrin Krause, Amal O Amer
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Mar 29, 2002·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Daniel R Prows, Michelle L Horner
Jul 29, 2019·Journal of Molecular Biology·Xin Liu, Sunny Shin

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