Natural selection and adaptive evolution of leptin in the ochotona family driven by the cold environmental stress.

PloS One
Jie YangHui Fang Tian

Abstract

Environmental stress can accelerate the evolutionary rate of specific stress-response proteins and create new functions specialized for different environments, enhancing an organism's fitness to stressful environments. Pikas (order Lagomorpha), endemic, non-hibernating mammals in the modern Holarctic Region, live in cold regions at either high altitudes or high latitudes and have a maximum distribution of species diversification confined to the Qinghai-Tibet Plateau. Variations in energy metabolism are remarkable for them living in cold environments. Leptin, an adipocyte-derived hormone, plays important roles in energy homeostasis. To examine the extent of leptin variations within the Ochotona family, we cloned the entire coding sequence of pika leptin from 6 species in two regions (Qinghai-Tibet Plateau and Inner Mongolia steppe in China) and the leptin sequences of plateau pikas (O. curzonia) from different altitudes on Qinghai-Tibet Plateau. We carried out both DNA and amino acid sequence analyses in molecular evolution and compared modeled spatial structures. Our results show that positive selection (PS) acts on pika leptin, while nine PS sites located within the functionally significant segment 85-119 of leptin and one uni...Continue Reading

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Datasets Mentioned

BETA
DQ983189
EF091861
EF091863
EF091864
EF091862
EF091860
DQ983190
DQ983191

Methods Mentioned

BETA
environmental stress
environmental stresses

Software Mentioned

BLAST
SEQBOOT
Sspro8
CODEML
PRODIST
MotifScan
ACCpro
SCRATCH
ModelTest3
DNAPARS

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