Mar 31, 2020

Characterization of dynamic age-dependent changes and driver microbes in primate gut microbiota during host's development and healthy aging via captive crab-eating macaque model

BioRxiv : the Preprint Server for Biology
Anja RaschkeMarcel Quint

Abstract

Recent population studies have significantly advanced our understanding of how age shapes the gut microbiota. However, the actual role of age could be inevitably confounded due to varying environmental factors in human populations. A well-controlled environment is thus necessary to reduce undesirable cofounding effects, and recapitulate age-dependent taxonomic and functional changes in the healthy primate gut microbiota. Herein we performed 16S rRNA gene sequencing, characterized age-associated gut microbial profiles from infant to elderly crab-eating macaques reared in captivity, and systemically revealed lifelong dynamic changes of primate gut microbiota in the model. While the most significantly age-associated gut microbial taxa were mainly found in commensals such as Faecalibacterium, a set of suspicious pathogens such as Helicobacter were exclusively enriched in infants, pointing to their potential role in host development. Importantly, topology analysis indicated that the connectivity of gut microbial network was even more age-dependent than taxonomic diversity, with its tremendous decline probably linked to the host's healthy aging. NetShift analysis identified Prevotella 9, Rikenellaceae RC9 gut group and Megasphaera as...Continue Reading

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Mentioned in this Paper

Study
Biological Neural Networks
Quantitative Trait Loci
ELF3 protein, Arabidopsis
AN 1
Genes
Regulation of Biological Process
Affect (Mental Function)
Circadian Clocks
Auxins

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