Natural Variation and Genetic Determinants of Caenorhabditis elegans Sperm Size.

Genetics
Clotilde GimondChristian Braendle

Abstract

The diversity in sperm shape and size represents a powerful paradigm to understand how selection drives the evolutionary diversification of cell morphology. Experimental work on the sperm biology of the male-hermaphrodite nematode Caenorhabditis elegans has elucidated diverse factors important for sperm fertilization success, including the competitive superiority of larger sperm. Yet despite extensive research, the molecular mechanisms regulating C . elegans sperm size and the genetic basis underlying natural variation in sperm size remain unknown. To address these questions, we quantified male sperm size variation of a worldwide panel of 97 genetically distinct C. elegans strains, allowing us to uncover significant genetic variation in male sperm size. Aiming to characterize the molecular genetic basis of C. elegans male sperm size variation using a genome-wide association study, we did not detect any significant quantitative trait loci. We therefore focused on the genetic analysis of pronounced sperm size differences observed between recently diverged laboratory strains (N2 vs. LSJ1/2). Using mutants and quantitative complementation tests, we demonstrate that variation in the gene nurf-1 underlies the evolution of small sperm...Continue Reading

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Citations

May 20, 2020·G3 : Genes - Genomes - Genetics·Luke M NobleMatthew V Rockman
Apr 8, 2020·Frontiers in Cell and Developmental Biology·Chee Kiang EweJoel H Rothman
Feb 5, 2021·Science Advances·Paul VigneChristian Braendle
Feb 18, 2021·Development·Clément DuboisMarie-Anne Félix

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