Natural Variation of Epstein-Barr Virus Genes, Proteins, and Primary MicroRNA

Journal of Virology
Samantha CorreiaP J Farrell

Abstract

Viral gene sequences from an enlarged set of about 200 Epstein-Barr virus (EBV) strains, including many primary isolates, have been used to investigate variation in key viral genetic regions, particularly LMP1, Zp, gp350, EBNA1, and the BART microRNA (miRNA) cluster 2. Determination of type 1 and type 2 EBV in saliva samples from people from a wide range of geographic and ethnic backgrounds demonstrates a small percentage of healthy white Caucasian British people carrying predominantly type 2 EBV. Linkage of Zp and gp350 variants to type 2 EBV is likely to be due to their genes being adjacent to the EBNA3 locus, which is one of the major determinants of the type 1/type 2 distinction. A novel classification of EBNA1 DNA binding domains, named QCIGP, results from phylogeny analysis of their protein sequences but is not linked to the type 1/type 2 classification. The BART cluster 2 miRNA region is classified into three major variants through single-nucleotide polymorphisms (SNPs) in the primary miRNA outside the mature miRNA sequences. These SNPs can result in altered levels of expression of some miRNAs from the BART variant frequently present in Chinese and Indonesian nasopharyngeal carcinoma (NPC) samples. The EBV genetic varian...Continue Reading

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Citations

Sep 22, 2017·The Journal of Infectious Diseases·Carrie B ColemanRosemary Rochford
Apr 13, 2018·International Journal of Molecular Sciences·Mohsen NavariPier Paolo Piccaluga
Nov 3, 2017·Journal of Virology·Ivan BorozanVincent Ferretti
Jul 28, 2018·PLoS Pathogens·Jillian A BristolShannon C Kenney
Oct 16, 2018·Journal of Medical Virology·Aboud KouriehUNKNOWN SPLIT study group
Aug 21, 2018·Annual Review of Pathology·Paul J Farrell
Mar 26, 2019·The Journal of General Virology·Ying GaoXiaozhen Liang
Apr 9, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ray BridgesPaul J Farrell
Mar 5, 2020·Journal of Medical Virology·Evelina ShikovaUNKNOWN European Network on ME/CFS (EUROMENE)
Aug 17, 2018·Journal of Virology·Samantha CorreiaPaul J Farrell
Apr 3, 2020·Journal of Virology·Nicholas A SmithRosemary Rochford
Jul 10, 2019·Scientific Reports·Louise ZanellaPriscilla Brebi
Sep 3, 2019·Frontiers in Immunology·Jonas BlombergCarl-Gerhard Gottfries
Dec 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lijun JiangKa-Leung Wong
May 14, 2020·Pathogens·Snježana Židovec LepejPetra Korać
Aug 11, 2019·Molecular Therapy. Nucleic Acids·Man WangKun Wang
Feb 27, 2021·Scientific Reports·Sina RüegerUNKNOWN Swiss HIV Cohort Study
Mar 5, 2021·Journal of Virology·Haiwen ChenMiao Xu

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Datasets Mentioned

BETA
LN827544
LN827527

Methods Mentioned

BETA
PCR
PCA
reverse transcription-PCR
biopsy

Software Mentioned

Macvector
Bootscan

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