Natural vegetable fats in the prevention of irritant contact dermatitis

Contact Dermatitis
S Schliemann-WillersP Elsner

Abstract

Chronic irritant contact dermatitis (ICD) is one of the most pressing problems in occupational medicine and is common in the food processing industry. To date, protective creams that fulfil the special requirements in the foodstuffs industry have not been available. Therefore, we studied the efficacy of pre-exposure application of natural vegetable fats in the prevention of experimentally induced ICD. A panel of 20 healthy volunteers was tested with a repetitive irritation test using sodium lauryl sulfate (SLS) as a standard irritant in a randomized study. Application sites were assessed clinically and by the use of bioengineering techniques (evaporimetry, chromametry, and corneometry). Rape seed and palm fats showed significant protective potential. Gas-chromatographic analysis revealed differences in the fatty acid composition of the vegetable. Higher content of linoleic acid and lower content of oleic acid was associated with beneficial effects. Our results are a new approach in the prevention of ICD and towards the development of new protective preparations for workplaces in the foodstuffs industry.

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Citations

Apr 9, 2005·Journal of Ethnopharmacology·A A Al-QarawiS A El-Mougy
Aug 10, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Yutaka TakagiGenji Imokawa
Dec 5, 2008·The Journal of Hospital Infection·Harald Löffler, Günter Kampf
Oct 26, 2005·Journal of the American Academy of Dermatology·Joan SaaryLinn Holness
Dec 24, 2011·Pharmaceutical Development and Technology·H O AmmarA M Ghoneim
Jul 15, 2017·American Journal of Clinical Dermatology·Alexandra R VaughnVivian Y Shi
Oct 28, 2019·Phytotherapy Research : PTR·Nina PoljšakNina Kočevar Glavač

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