Naturalistic follow-up after a trial of medications for opioid use disorder: Medication status, opioid use, and relapse.

Journal of Substance Abuse Treatment
Miranda G GreinerEdward V Nunes

Abstract

This report examined naturalistic opioid use outcomes and utilization of medications for opioid use disorder (MOUD) 36 weeks post-randomization in the National Drug Abuse Treatment Clinical Trials Network (CTN) Extended-Release Naltrexone (XR-NTX) versus Buprenorphine-Naloxone (BUP-NX) for Opioid Treatment trial (CTN-0051, X:BOT). X:BOT was a multisite, randomized, 24-week comparative effectiveness trial of BUP-NX (N = 287) and XR-NTX (N = 283). Study medications were discontinued following treatment completion, relapse, or dropout. Participants were encouraged to continue MOUD. This report examined opioid use outcomes in 428 (75%) of the 570 participants who attended the 36-week follow-up visit. Adults with opioid use disorder recruited from 8 community treatment programs across the United States. Outcomes included medication status (on/off MOUD), type of MOUD (BUP-NX, XR-NTX, or methadone), abstinence from non-prescribed opioids, opioid use days, relapse, and other substance use 30 days prior to the 36-week visit. Relapse was defined as opioid use for 4 consecutive weeks or 7 consecutive days in the past month. Baseline and clinical variables included opioid use severity, intravenous drug use, study medication assignment, and...Continue Reading

References

Mar 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·M GossopB Bradley
Feb 11, 2000·Drug and Alcohol Dependence·B BroersA Mino
Oct 4, 2000·JAMA : the Journal of the American Medical Association·A T McLellanH D Kleber
May 16, 2001·Archives of General Psychiatry·Y I HserM D Anglin
May 25, 2001·The American Journal of Drug and Alcohol Abuse·M A ChutuapeM L Stitzer
Jul 24, 2003·The Journal of Behavioral Health Services & Research·Gregory Bovasso, John Cacciola
Sep 13, 2005·Drug and Alcohol Dependence·Anna WilliamsonMaree Teesson
Dec 20, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hendrik G RoozenAd J F M Kerkhof
Dec 18, 2008·Journal of General Internal Medicine·Joshua D LeeMarc N Gourevitch
Apr 22, 2010·Journal of Addictive Diseases·Mary Jeanne KreekBrenda Ray
Jul 6, 2012·The American Journal of Psychiatry·Jari TiihonenEdwin Zwartau
Jun 22, 2013·Journal of Substance Abuse Treatment·Genie L BaileyMichael D Stein
Aug 5, 2014·JAMA Internal Medicine·Jane M LiebschutzMichael Stein
Oct 2, 2014·Psychiatric Services : a Journal of the American Psychiatric Association·Colleen L BarryHoward H Goldman
Jan 15, 2015·Annals of Family Medicine·Roger A RosenblattEric H Larson
Jan 21, 2015·Journal of Substance Abuse Treatment·Brandon S BentzleySarah W Book
Mar 10, 2015·Harvard Review of Psychiatry·Yih-Ing HserDouglas Anglin
Oct 16, 2015·Journal of Addictive Diseases·Christine TimkoChristina Garrison-Diehn
Mar 31, 2016·The New England Journal of Medicine·Joshua D LeeCharles P O'Brien
Mar 23, 2017·The American Journal on Addictions·Arthur Robin WilliamsAdam Bisaga
May 6, 2017·Journal of Substance Abuse Treatment·Edward V NunesCharles P O'Brien
Aug 22, 2018·Journal of Substance Abuse Treatment·Christopher W JonesRachel Haroz
Jan 25, 2019·The American Journal of Drug and Alcohol Abuse·Arthur Robin WilliamsMark Olfson
Mar 14, 2019·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Jonathan AveryJulie B Penzner

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