Naturalistic outcomes of minor and subsyndromal depression in older primary care patients

International Journal of Geriatric Psychiatry
J M Lyness

Abstract

To review the literature regarding the naturalistic outcomes of minor and subsyndromal depression ('Min/SSD') in older primary care patients, synthesizing and critiquing findings and discussing avenues for future research. The author obtained relevant articles from repeated computer-assisted literature searches over the past 15 years, and by reviewing the reference citations of the articles so obtained. A variety of relevant outcome domains were identified, as were important putative predictors, moderators, and mediators of outcome. In general, minor and subsyndromal depression each have comparable outcomes, outcomes that are clearly worse than non-depressed subjects, with substantially elevated risk of worsening into major depression, albeit not as poor as those with major depression. Min/SSD is common and of real clinical importance in primary care seniors. Several definitions of SSD may be used, each with overlapping but distinguishable utility in identifying patients. While the evidence base has expanded greatly in the past decade, considerable work remains to be done. Naturalistic studies of several outcome domains are needed, focusing on the predictive, moderating, and mediating roles of a wide range of psychopathological...Continue Reading

References

Dec 1, 1992·The American Journal of Psychiatry·H G KoenigB DiPasquale
Jul 1, 1992·Journal of Clinical Epidemiology·K PahkalaP Laippala
Jan 1, 1992·Journal of Gerontology·P A ParmeleeM P Lawton
May 1, 1990·Annals of Internal Medicine·M E Williams
Jul 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·C F DugganR M Murray
Dec 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·J P EmmersonW Hall
Mar 1, 1986·Journal of Affective Disorders·W A KukullJ L Gale
May 1, 1988·Psychological Medicine·M Shepherd, G Wilkinson
Jun 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·R M HirschfeldM B Keller
May 1, 1986·Journal of the American Geriatrics Society·S BorsonM A Raskind
Oct 1, 1995·Archives of General Psychiatry·G E SimonW Barlow
Mar 1, 1995·The American Journal of Psychiatry·G SimonW Barlow
Aug 1, 1994·Journal of the American Geriatrics Society·C M CallahanW M Tierney
Jun 1, 1994·Journal of Affective Disorders·W KatonP Robinson
Sep 1, 1993·Journal of Gerontology·J M Guralnik, E M Simonsick
Jun 1, 1993·The American Journal of Psychiatry·J M LynessC Cox
Feb 1, 1996·Journal of the American Geriatrics Society·J M LynessC F Reynolds
Jul 1, 1996·The American Journal of Psychiatry·G S AlexopoulosJ Clarkin
Sep 1, 1996·The American Journal of Psychiatry·B S GreenwaldM Patel
Oct 1, 1996·Archives of General Psychiatry·M OlfsonR Kathol
Jan 1, 1997·Annual Review of Medicine·A RozenzweigC F Reynolds
Apr 1, 1997·The American Journal of Psychiatry·K R KrishnanD G Blazer
Mar 1, 1997·The Psychiatric Clinics of North America·D C Woolley
May 28, 1997·JAMA : the Journal of the American Medical Association·J UnützerW Katon
Oct 27, 1997·JAMA : the Journal of the American Medical Association·B D LebowitzP Parmelee
Oct 27, 1997·The American Journal of Psychiatry·G S ZubenkoX M Tu
Oct 24, 1997·Archives of General Psychiatry·G S AlexopoulosM Charlson
Apr 8, 1998·Journal of the International Neuropsychological Society : JINS·D A KingE D Caine
Jun 12, 1998·JAMA : the Journal of the American Medical Association·B W PenninxR B Wallace
Jul 11, 1998·The American Journal of Psychiatry·J M LynessE D Caine
Feb 19, 1999·Psychosomatic Medicine·L R WulsinV E Wells
Feb 19, 1999·Psychosomatic Medicine·F Lespérance, N Frasure-Smith
Mar 17, 1999·Journal of the American Geriatrics Society·D C SteffensK R Krishnan
Apr 16, 1999·Journal of General Internal Medicine·J M LynessZ Yoediono
Apr 20, 1999·International Journal of Psychiatry in Medicine·H C SchulbergC F Reynolds
Apr 22, 1999·The British Journal of Psychiatry : the Journal of Mental Science·H G PrigersonS Zisook
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·D C SteffensG L Burke
Mar 11, 2000·Archives of General Psychiatry·G S AlexopoulosJ Hull

❮ Previous
Next ❯

Citations

Oct 29, 2011·European Archives of Psychiatry and Clinical Neuroscience·Thomas C BaghaiUNKNOWN Section of Pharmacopsychiatry, World Psychiatric Association
Sep 13, 2008·International Psychogeriatrics·Jeffrey M LynessPaul R Duberstein
May 13, 2010·Journal of Gerontological Social Work·Zvi D Gellis
Feb 7, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Eran ChemerinskiPhilip D Harvey
Sep 3, 2010·BMC Family Practice·Elizabeth PhelanMark Snowden
Apr 23, 2005·BMC Family Practice·James E RohrerAnthony Way
Mar 9, 2010·Journal of the American Board of Family Medicine : JABFM·Marnin J HeiselMitchell D Feldman
Jan 1, 2008·Primary Care Companion to the Journal of Clinical Psychiatry·Maria MagnilCecilia Björkelund
Mar 6, 2013·Current Translational Geriatrics and Experimental Gerontology Reports·Namkee G ChoiMartha L Bruce
Mar 13, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ipsit V VahiaDilip V Jeste
Jan 23, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Stefan WiktorssonMargda Waern
Jun 2, 2009·Archives of Physical Medicine and Rehabilitation·Gary P Epstein-LubowIvan W Miller
Sep 16, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Shoshana L WooP Murali Doraiswamy
Oct 13, 2011·International Journal of Geriatric Psychiatry·Ricardo Barcelos-FerreiraCássio M C Bottino
Jul 23, 2013·Journal of Affective Disorders·Arwa AburizikCarolyn Turvey
Apr 16, 2013·Journal of Aging and Health·Namkee G ChoiNancy Wilson
Apr 13, 2017·International Journal of Geriatric Psychiatry·Laura N GitlinDavid L Roth
Jan 1, 2017·Psychiatry Research. Neuroimaging·Molly E McLarenVonetta M Dotson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.