Abstract
The newer atypical antipsychotics have gained prominence as first-line oral agents to treat severe agitation, but their use in the psychiatric emergency service (PES) setting has been limited because of the unavailability of parenteral formulations. The advent of parenteral formulations of atypical antipsychotics, beginning with ziprasidone in 2002, might afford an alternative treatment option. The objective of this article was to determine the effectiveness and tolerability of i.m. ziprasidone used to treat agitation in elderly patients. In this data analysis, the PES database at the Department of Psychiatry and Behavioral Science, School of Medicine, State University of New York, Stony Brook, New York, was searched for records of patients aged > or = 65 years who received a single 20-mg dose of i.m. ziprasidone for the treatment of acute agitation. Efficacy data from these patients were compared with those from an age- and gender-matched sample that received conventional treatment (CT group) with i.m. haloperidol, with or without lorazepam. Data were also included from a previous naturalistic outcomes study to determine the effectiveness and tolerability of i.m. ziprasidone in patients treated at the PES at Stony Brook. Addit...Continue Reading
References
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·D E Casey
Jul 1, 1997·The American Journal of Emergency Medicine·J BattagliaL Goodman
Feb 24, 2001·The Journal of Clinical Psychiatry·S BrookK P Gunn
Jun 13, 2001·Psychopharmacology·D G DanielE P Harrigan
Nov 3, 2001·The American Journal of Psychiatry·A H Glassman, J T Bigger
Jan 5, 2002·CNS Drugs·Daniel TarsyFrank I Tarazi
Jan 5, 2002·Journal of Psychiatric Research·R H SwiftL P Chandler
Apr 12, 2002·CNS Drugs·Glenn W Currier, Adam Trenton
May 2, 2002·Archives of General Psychiatry·Alan BreierPadraig Wright
Oct 31, 2002·Human Psychopharmacology·Shlomo Brook
Mar 18, 2003·Journal of Clinical Psychopharmacology·Catherine M RoeRochelle R Henderson
Mar 10, 2005·Zeitschrift für Gerontologie und Geriatrie·J P H Hamers, A R Huizing
Mar 15, 2005·General Hospital Psychiatry·Horacio PrevalAndrew Francis
May 27, 2005·Drugs·John Battaglia
Jun 30, 2005·Journal of Psychiatric Practice·Peter J WeidenRuth Ross
Jul 15, 2005·The Journal of Clinical Psychiatry·K Elizabeth GrecoWilliam A Van Horn
Dec 13, 2005·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Mark L Moster, Laura J Balcer
Citations
Mar 17, 2009·Child and Adolescent Psychiatry and Mental Health·William C JangroAndrew Francis
Feb 19, 2008·CNS Drugs·Dan L Zimbroff
Feb 5, 2009·The Journal of Clinical Psychiatry·Theodore D SatterthwaiteStanley N Caroff
Jan 31, 2013·The Journal of Emergency Medicine·Connie SwickhamerShu B Chan
Sep 9, 2011·Internal Medicine Journal·C PeisahS G Reutens
Jan 1, 2011·Journal of Central Nervous System Disease·Chiara MatteiStephen M Stahl
Feb 27, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Matthew RizzoRobert Rodnitzky
Feb 14, 2012·The American Journal of Drug and Alcohol Abuse·Thomas D MarcotteSandra A Brown