PMID: 16503319Mar 1, 2006Paper

Naturalistic study of intramuscular ziprasidone versus conventional agents in agitated elderly patients: retrospective findings from a psychiatric emergency service

The American Journal of Geriatric Pharmacotherapy
Izchak KohenAndrew Francis

Abstract

The newer atypical antipsychotics have gained prominence as first-line oral agents to treat severe agitation, but their use in the psychiatric emergency service (PES) setting has been limited because of the unavailability of parenteral formulations. The advent of parenteral formulations of atypical antipsychotics, beginning with ziprasidone in 2002, might afford an alternative treatment option. The objective of this article was to determine the effectiveness and tolerability of i.m. ziprasidone used to treat agitation in elderly patients. In this data analysis, the PES database at the Department of Psychiatry and Behavioral Science, School of Medicine, State University of New York, Stony Brook, New York, was searched for records of patients aged > or = 65 years who received a single 20-mg dose of i.m. ziprasidone for the treatment of acute agitation. Efficacy data from these patients were compared with those from an age- and gender-matched sample that received conventional treatment (CT group) with i.m. haloperidol, with or without lorazepam. Data were also included from a previous naturalistic outcomes study to determine the effectiveness and tolerability of i.m. ziprasidone in patients treated at the PES at Stony Brook. Addit...Continue Reading

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Citations

Mar 17, 2009·Child and Adolescent Psychiatry and Mental Health·William C JangroAndrew Francis
Feb 5, 2009·The Journal of Clinical Psychiatry·Theodore D SatterthwaiteStanley N Caroff
Jan 31, 2013·The Journal of Emergency Medicine·Connie SwickhamerShu B Chan
Jan 1, 2011·Journal of Central Nervous System Disease·Chiara MatteiStephen M Stahl
Feb 27, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Matthew RizzoRobert Rodnitzky
Feb 14, 2012·The American Journal of Drug and Alcohol Abuse·Thomas D MarcotteSandra A Brown

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