PMID: 18209933Jan 23, 2008Paper

Naturally acquired antibodies to merozoite surface protein (MSP)-1(19) and cumulative exposure to Plasmodium falciparum and Plasmodium vivax in remote populations of the Amazon Basin of Brazil

Memórias do Instituto Oswaldo Cruz
Simone Ladeia-AndradeJosé Rodrigues Coura

Abstract

To infer recent patterns of malaria transmission, we measured naturally acquired IgG antibodies to the conserved 19-kDa C-terminal region of the merozoite surface protein (MSP)-1 of both Plasmodium vivax (PvMSP-1(19)) and Plasmodium falciparum (PfMSP-1(19)) in remote malaria-exposed populations of the Amazon Basin. Community-based cross-sectional surveys were carried out between 2002 and 2003 in subjects of all age groups living along the margins of the Unini and Jaú rivers, Northwestern Brazil. We found high prevalence rates of IgG antibodies to PvMSP-1(19) (64.0 - 69.6%) and PfMSP-1(19) (51.6 - 52.0%), with significant differences in the proportion of subjects with antibodies to PvMSP-1(19) according to age, place of residence and habitual involvement in high-risk activities, defining some groups of highly exposed people who might be preferential targets of malaria control measures. In contrast, no risk factor other than age was significantly associated with seropositivity to PfMSP-1(19). Only 14.1% and 19.3% of the subjects tested for antibodies to PvMSP-1(19) and PfMSP-1(19) in consecutive surveys (142 - 203 days apart) seroconverted or had a three fold or higher increase in the levels of antibodies to these antigens. We di...Continue Reading

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Citations

May 4, 2010·Malaria Journal·Joseli Oliveira-FerreiraCláudio Tadeu Daniel-Ribeiro
Jan 15, 2010·Malaria Journal·Bruno B AndradeManoel Barral-Netto
Oct 1, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Jordi Gómez I PratCarlos Ascaso
May 8, 2018·Scientific Reports·Leonardo Suveges Moreira ChavesMaria Anice Mureb Sallum

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