Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo.

Emerging Infectious Diseases
Thamayanthi Nada RajaBalbir Singh

Abstract

To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR assays, we found 845 (80.6%) patients had either P. knowlesi monoinfection (n = 815) or co-infection with other Plasmodium species (n = 30). We noted the annual number of these zoonotic infections increased greatly in 2017 (n = 284). We identified 6 patients, 17-65 years of age, with P. cynomolgi and P. knowlesi co-infections, confirmed by phylogenetic analyses of the Plasmodium cytochrome c oxidase subunit 1 gene sequences. P. knowlesi continues to be a public health concern in the Kapit Division of Sarawak, Malaysian Borneo. In addition, another simian malaria parasite, P. cynomolgi, also is an emerging cause of malaria in humans.

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Citations

Jan 26, 2021·PLoS Neglected Tropical Diseases·Meizhi Irene LiCheong Huat Tan
Feb 4, 2021·Malaria Journal·Kimberly M FornaceChris J Drakeley
Mar 20, 2021·Frontiers in Cellular and Infection Microbiology·Damilola R OresegunJanet Cox-Singh
May 1, 2021·Tropical Medicine and Infectious Disease·Alexander Bykersma
May 28, 2021·Clinical Microbiology Reviews·Mateusz PlucinskiEric Rogier
Jul 28, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Donelly A van SchalkwykColin J Sutherland

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Methods Mentioned

BETA
PCR

Software Mentioned

Tree Annotator
MEGA7
FigTree
BEAST
Tracer
ClustalX

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