Naturally acquired immune responses against Plasmodium falciparum sporozoites and liver infection.

International Journal for Parasitology
Vittoria OffedduKai Matuschewski

Abstract

Malaria is a vector-borne infectious disease caused by infection with eukaryotic pathogens termed Plasmodium. Epidemiological hallmarks of Plasmodium falciparum malaria are continuous re-infections, over which time the human host may experience several clinical malaria episodes, slow acquisition of partial protection against infection, and its partial decay upon migration away from endemic regions. To overcome the exposure-dependence of naturally acquired immunity and rapidly elicit robust long-term protection are ultimate goals of malaria vaccine development. However, cellular and molecular correlates of naturally acquired immunity against either parasite infection or malarial disease remain elusive. Sero-epidemiological studies consistently suggest that acquired immunity is primarily directed against the asexual blood stages. Here, we review available data on the relationship between immune responses against the Anopheles mosquito-transmitted sporozoite and exo-erythrocytic liver stages and the incidence of malaria. We discuss current limitations and research opportunities, including the identification of additional sporozoite antigens and the use of systematic immune profiling and functional studies in longitudinal cohorts t...Continue Reading

References

Jan 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·M D WijesunderaG Del Giudice
Apr 1, 1988·European Journal of Immunology·F SinigagliaJ R Pink
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·K MarshB M Greenwood
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·C ChizzoliniG del Giudice
May 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·M R HollingdaleA Bjorkmann
Sep 4, 1986·The New England Journal of Medicine·S L HoffmanW T Hockmeyer
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y ZeveringM F Good
Apr 1, 1994·Molecular and Biochemical Parasitology·D A FidockA Asavanich
Mar 1, 1995·Parasite : Journal De La Société Française De Parasitologie·M F Ferreira-da-CruzC T Daniel-Ribeiro
Apr 27, 2001·Trends in Parasitology·J D KurtisP E Duffy
May 24, 2001·The Journal of Biological Chemistry·T V NguyenA A James
Jun 1, 1996·Parasitology Today·J F Trape, C Rogier
Sep 14, 2004·Immunological Reviews·Siske S Struik, Eleanor M Riley
Jan 5, 2005·The Journal of Experimental Medicine·Alida CoppiPhotini Sinnis
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·D Huw DaviesPhilip L Felgner
Aug 12, 2005·The Pediatric Infectious Disease Journal·Kiprotich ChelimoChandy C John

❮ Previous
Next ❯

Citations

Nov 2, 2013·Trends in Parasitology·Danielle I StanisicMichael F Good
Mar 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tuan M TranPeter D Crompton
Mar 25, 2014·Annual Review of Immunology·Peter D CromptonSusan K Pierce
Aug 16, 2012·Microbes and Infection·Ana Claudia TorrecilhasWalter Colli
Oct 4, 2015·Vaccine·David C Kaslow, Sophie Biernaux
Oct 16, 2015·Vaccine·Wiebke NahrendorfJean Langhorne
Oct 7, 2015·Frontiers in Microbiology·Rhea J LongleyAlexandra J Spencer
Dec 20, 2012·Human Vaccines & Immunotherapeutics·Kai Matuschewski
Mar 25, 2014·Molecular and Biochemical Parasitology·Vittoria OffedduKai Matuschewski
Jun 5, 2012·International Journal for Parasitology·Jake BaumBrian M Cooke
Dec 3, 2014·Frontiers in Microbiology·Wan Ni ChiaLaurent Rénia
Dec 6, 2014·Frontiers in Microbiology·Johanna N DupsIan A Cockburn
Jan 30, 2018·Pathogens and Global Health·Stephanie Tannous, Esther Ghanem
Jan 15, 2015·Infection and Immunity·Peter LiehlMiguel Prudêncio
Sep 17, 2013·Nature Reviews. Microbiology·Robert MénardRogerio Amino
Jan 22, 2017·Cold Spring Harbor Perspectives in Medicine·Friedrich Frischknecht, Kai Matuschewski
Jun 18, 2017·Frontiers in Cellular and Infection Microbiology·Oriana KreutzfeldKai Matuschewski
Jun 15, 2018·PLoS Neglected Tropical Diseases·Lou S HermanKevin K A Tetteh
Feb 19, 2019·Frontiers in Immunology·Aloysious SsemagandaMichael F Good
Jan 9, 2019·Frontiers in Immunology·Katrien Deroost, Jean Langhorne
May 14, 2017·The American Journal of Tropical Medicine and Hygiene·Scott D NashPatrick E Duffy
Apr 4, 2019·Nature Reviews. Immunology·Samarchith P KurupJohn T Harty
Dec 3, 2017·Immunity·Gianna TrillerHedda Wardemann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.