Naturally acquired microchimerism.

The International Journal of Developmental Biology
H S Gammill, J Lee Nelson

Abstract

Bi-directional transplacental trafficking occurs routinely during the course of normal pregnancy, from fetus to mother and from mother to fetus. In addition to a variety of cell-free substances, it is now well recognized that some cells are also exchanged. Microchimerism refers to a small number of cells (or DNA) harbored by one individual that originated in a genetically different individual. While microchimerism can be the result of iatrogenic interventions such as transplantation or transfusion, by far the most common source is naturally acquired microchimerism from maternal-fetal trafficking during pregnancy. Microchimerism is a subject of much current interest for a number of reasons. During pregnancy, fetal microchimerism can be sought from the mothers blood for the purpose of prenatal diagnosis. Moreover, studies of fetal microchimerism during pregnancy may offer insight into complications of pregnancy, such as preeclampsia, as well as insights into the pathogenesis of autoimmune diseases such as rheumatoid arthritis which usually ameliorates during pregnancy. Furthermore, it is now known that microchimerism persists decades later, both fetal microchimerism in women who have been pregnant and maternal microchimerism in h...Continue Reading

References

Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L A HerzenbergG M Iverson
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D W BianchiS A Latt
Apr 1, 1974·Transplantation·J SchröderA De la Chapelle
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W BianchiM A DeMaria
May 1, 1996·Biology of Reproduction·P Piotrowski, B A Croy
Aug 16, 1997·Lancet·Y M LoJ S Wainscoat
Oct 23, 1997·American Journal of Human Genetics·D W BianchiA P Shuber
Apr 18, 1998·Nature Medicine·A Tyndall, A Gratwohl
Apr 29, 1998·The New England Journal of Medicine·C M ArtlettS A Jimenez
Apr 29, 1998·The New England Journal of Medicine·J L Nelson
May 8, 1998·Obstetrics and Gynecology·W HolzgreveS Hahn
Nov 13, 1998·Current Opinion in Rheumatology·J L Nelson
Dec 24, 1998·Lancet·S AractingiE D Carosella
Jan 23, 1999·American Journal of Human Genetics·Y M LoN M Hjelm
Jul 7, 1999·The Journal of Clinical Investigation·S MaloneyJ L Nelson
Jul 31, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D V SurbekW Holzgreve
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TanakaM E Gershwin
Dec 28, 1999·Human Reproduction·R Al-MuftiK H Nicolaides
Sep 14, 2000·The Journal of Laboratory and Clinical Medicine·E CarrierM Zanetti
Sep 19, 2000·Annals of the Rheumatic Diseases·Y MiyashitaK Kurasawa
Nov 30, 2000·Journal of Hepatology·P A FanningE E Powell
Nov 30, 2000·Journal of Hepatology·C CorpechotR Poupon
Jan 9, 2001·Dermatology : International Journal for Clinical and Investigative Dermatology·R TaneiK Katsuoka
Feb 24, 2001·Lancet·A M ReedD W Kredich
Mar 27, 2001·Lancet·A Selva-O'CallaghanM Vilardell-Tarrés
May 16, 2001·Arthritis and Rheumatism·N IchikawaN Kamatani
Aug 18, 2001·Arthritis and Rheumatism·K L JohnsonD W Bianchi
Sep 6, 2001·Annals of the Rheumatic Diseases·T Mijares-Boeckh-BehrensE Balada-Prades
Oct 11, 2001·Arthritis and Rheumatism·K L JohnsonD W Bianchi
Nov 1, 2001·Archives of Dermatological Research·T OhtsukaS Yamazaki
Nov 16, 2001·Rheumatology·C M ArtlettUNKNOWN Childhood Myositis Heterogeneity Collaborative Study Group
Dec 26, 2001·Endocrinology·M ImaizumiT F Davies

❮ Previous
Next ❯

Citations

Jul 20, 2012·Rheumatology International·Asli Gamze Sener, Ilhan Afsar
Feb 4, 2011·The Journal of Infectious Diseases·Jennifer M BabikJoseph M McCune
Aug 28, 2012·Case Reports in Pediatrics·Tomoaki IshikawaHiroshi Suzuki
Mar 20, 2012·Veterinary Research·Uladzimir U KarniychukHans J Nauwynck
Sep 14, 2011·PloS One·Hilary S GammillJ Lee Nelson
Oct 11, 2012·PloS One·William F N ChanJ Lee Nelson
Mar 22, 2014·PloS One·Miranda P DierselhuisEls Goulmy
Dec 12, 2012·Viruses·Armelle Le CampionHugo Soudeyns
Dec 12, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Irina Polejaeva, Shoukhrat Mitalipov
Feb 12, 2013·Seminars in Pediatric Surgery·Amar Nijagal, Tippi C MacKenzie
May 23, 2012·Trends in Immunology·J Lee Nelson
Feb 23, 2011·Differentiation; Research in Biological Diversity·Mariusz Z RatajczakDong-Myung Shin
Dec 2, 2015·Lancet Neurology·Annette Langer-Gould
Feb 26, 2013·American Journal of Reproductive Immunology : AJRI·Trevor D Burt
Sep 29, 2011·Arthritis and Rheumatism·William F N ChanJ Lee Nelson
Mar 2, 2011·Arthritis and Rheumatism·Zhen YanJ Lee Nelson
Jul 14, 2011·American Journal of Reproductive Immunology : AJRI·Ghina GhazeeriOssama Abbas
Mar 3, 2012·American Journal of Reproductive Immunology : AJRI·Kenneth D BeamanAlice Gilman-Sachs
Jul 14, 2010·American Journal of Reproductive Immunology : AJRI·Leela E Noronha, Douglas F Antczak
Feb 8, 2013·International Journal of Cancer. Journal International Du Cancer·Eugen DhimoleaPeter Geck
Feb 28, 2014·Arthritis & Rheumatology·Kimberly K MaHilary S Gammill
Feb 26, 2013·The Journal of Allergy and Clinical Immunology·Emma E ThompsonCarole Ober
Jan 1, 2011·Pregnancy Hypertension·Carl A HubelIan P Crocker
Aug 27, 2013·Chimerism·Kimberly K MaKristina M Adams Waldorf
Feb 14, 2012·Medical Hypotheses·Marc Schnitzler, Paul Fisch
Jul 8, 2010·Journal of Reproductive Immunology·Henriette Svarre NielsenFrans Claas
Sep 15, 2016·Chimerism·Amanda Cecilie MüllerMads Kamper-Jørgensen
Jan 8, 2011·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Osamu Samura
May 10, 2017·Nature Reviews. Immunology·Jeremy M KinderSing Sing Way
Oct 14, 2017·Briefings in Functional Genomics·Anders StåhlbergThomas Kroneis
Aug 14, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·R ShreeH S Gammill
Oct 9, 2013·Hypertension·Hilary S GammillJ Lee Nelson
Feb 20, 2019·Cells·Greggory S LabergeJohn Pawelek

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