PMID: 9539952Apr 16, 1998Paper

Naturally occurring 2'-O-methylpurine nucleosides with hypotensive properties

Cellular and Molecular Life Sciences : CMLS
T YamadaK Ienaga

Abstract

2'-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2'-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.

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