Naturally occurring benzoic acid derivatives retard cancer cell growth by inhibiting histone deacetylases (HDAC)

Cancer Biology & Therapy
Preethi G AnantharajuSubbaRao V Madhunapantula

Abstract

Histone deacetylases (HDACs), which modulate the expression of genes, are potential therapeutic targets in several cancers. Targeted inhibition of HDAC prevents the expression of oncogenes thereby help in the treatment of cancers. Hence, several pharmaceutical companies developed inhibitors of HDAC and tested them in preclinical models and in clinical trials. SAHA (suberanilohydroxamic acid) is one such HDAC inhibitor developed for treating breast and colorectal carcinomas. However, due to poor efficacy in clinical trials the utility of SAHA for treating cancers was discouraged. Similarly another HDAC inhibitor Trichostatin-A (TSA) also showed promising results in clinical trials but exhibited severe adverse effects, which dampened the interest of using this molecule for cancer treatment. Therefore, search for developing a potent HDAC inhibitor with minimal side effects still continues. Hence, in this study we have screened benzoic acid and benzoic acid derivatives with hydroxylic (-OH) groups and methoxy (-OCH3) groups for their efficacy to bind to the TSA binding site of HDAC using molecular docking studies. Molecules that showed much stronger affinity (than TSA) to HDAC were tested for inhibiting HDAC expressing cultured can...Continue Reading

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Jul 1, 1989·Analytical Biochemistry·R E BrownK J Hyland
Dec 22, 1999·The Journal of Clinical Investigation·W R Sellers, D E Fisher
Aug 3, 2000·Journal of the National Cancer Institute·P A MarksR A Rifkind
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Nov 11, 2003·BMC Cancer·José Manuel Afonso MoreiraPoul Sørensen
Jul 27, 2004·Protein Science : a Publication of the Protein Society·Yigong Shi
Dec 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yufang ShaoXuejun Jiang
Sep 7, 2006·Nature Reviews. Drug Discovery·Jessica E BoldenRicky W Johnstone
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Dec 7, 2007·The Journal of Nutritional Biochemistry·Markus WaldeckerDieter Schrenk
May 17, 2008·Molecular Cancer Therapeutics·SubbaRao V MadhunapantulaGavin P Robertson
Jul 18, 2008·Molecular Biology of the Cell·Andrew J WilsonJohn M Mariadason
Apr 16, 2010·Bioorganic & Medicinal Chemistry Letters·Jerome C BressiAnthony R Gangloff
Apr 20, 2010·Plant Signaling & Behavior·Santi M MandalSatyahari Dey
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·J-H LeePaul A Marks
Mar 23, 2011·Nature Neuroscience·Ying ChenQ Richard Lu
Feb 12, 2013·Methods in Molecular Biology·Francis Ka-Ming ChanMaría José De Rosa
Mar 26, 2013·Nature Chemical Biology·Mercedes LoberaMichael A Nolan
Dec 4, 2013·Molecular Medicine Reports·Zhi-Hua ZhangCui-Min Zhu
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Diana UrregoLuis A Pardo
Feb 11, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Selvaraju KarthikVilwanathan Ravikumar
Mar 5, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Madhusoodanan MottamalGuangdi Wang
Mar 10, 2015·Critical Reviews in Oncogenesis·Hong Ping ChenTing C Zhao
Apr 4, 2015·Cold Spring Harbor Perspectives in Biology·David R McIlwainTak W Mak
Dec 3, 2016·Nutrition Journal·Preethi G AnantharajuSubbaRao V Madhunapantula

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Citations

May 6, 2019·Pathology Oncology Research : POR·Jingchun QinHuixuan Li
Feb 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jacek ŁyczkoAntoni Szumny
Dec 29, 2020·Colloids and Surfaces. B, Biointerfaces·Pallavi ChandVikas Jain
Aug 7, 2021·Saudi Journal of Biological Sciences·Aisha NawazZahida Parveen

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Methods Mentioned

BETA
X-ray
FACS

Software Mentioned

CDOCKER
Discovery Studio
Studio
Discovery
docker
Accelrys Discovery Studio
Biovia
CHARMm
FACS

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