PMID: 7535980Dec 1, 1994Paper

Naturally occurring human IgA autoantibodies against IgE-DES myeloma protein. Prevalence and specificity

Allergy
C G Magnusson

Abstract

The prevalence and specificity of naturally occurring human IgA anti-IgE autoantibodies (a-E Ab) were studied by ELISA with anti-IgA monoclonal antibodies (mAb) and a purified myeloma IgE as solid-phase protein, i.e., IgE-DES(kappa). Such detected IgA a-E Ab were common among adults, and significantly increased geometric means (GM) were found in patients with atopy (P = 0.006; n = 41; GM = 79.3 arbitrary units (AU)/ml) and filariasis (P = 0.02; n = 41; GM = 75.9 AU/ml), as compared with nonatopic controls (n = 42; GM = 48.8 AU/ml). No such difference was observed between age-matched nonatopic (n = 22; GM = 36.7 AU/ml) and atopic (n = 22; GM = 38.6 AU/ml) children. Children had significantly (P < 0.001) lower IgA a-E Ab concentrations than adults, probably as a result of age, because IgA a-E Ab concentrations and age of children were significantly correlated (n = 44; P < 0.05; r = 0.30). IgA a-E Ab concentrations were very low in cord serum (n = 32; median < 0.1 AU/ml). Sex did not influence IgA a-E Ab concentrations in any study group. The specificity of IgA a-E Ab in nine sera was studied by ELISA inhibition assay using IgE-DES myeloma as solid-phase protein and inhibitory proteins of the IgG, IgM, IgD, and IgE classes, includ...Continue Reading

References

Jan 1, 1991·International Archives of Allergy and Applied Immunology·B M StadlerA L de Weck
Mar 1, 1990·The Journal of Experimental Medicine·R C MonteiroM D Cooper
Jan 1, 1986·International Archives of Allergy and Applied Immunology·C G Magnusson, J P Vaerman
Jan 1, 1989·Journal of Medical Genetics·G WolffG Oepen
Aug 1, 1989·The Journal of Investigative Dermatology·G MaroneI Quinti
Jan 1, 1986·International Archives of Allergy and Applied Immunology·C G Magnusson, J P Vaerman
Aug 1, 1985·The Journal of Clinical Investigation·J E Persselin, R H Stevens
Apr 1, 1972·The Journal of Clinical Investigation·R C WilliamsR C Field
Jan 1, 1983·The Journal of Clinical Investigation·R S Geha, M Comunale
Jan 1, 1981·International Archives of Allergy and Applied Immunology·M InganäsH Bennich

❮ Previous
Next ❯

Citations

May 16, 1998·Autoimmunity·H M Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.