PMID: 9658089Jul 11, 1998Paper

Naturally occurring human immunodeficiency virus type 1 long terminal repeats have a frequently observed duplication that binds RBF-2 and represses transcription

Journal of Virology
Mario C EstableIvan Sadowski

Abstract

Approximately 38% of human immunodeficiency virus type 1 (HIV-1)-infected patients within the Vancouver Lymphadenopathy-AIDS Study have proviruses bearing partial 15- to 34-nucleotide duplications upstream of the NF-kappaB binding sites within the 5' long terminal repeat (LTR). This most frequent naturally occurring length polymorphism (MFNLP) of the HIV-1 5' LTR encompasses potential binding sites for several candidate transcription factors, including TCF-1alpha/hLEF, c-Ets, AP-4, and Ras-responsive binding factor 2 (RBF-2) (M. C. Estable et al., J. Virol. 70:4053-4062, 1996). RBF-2 and an apparently related factor, RBF-1, bind to at least four cis elements within the LTR which are required for full transcriptional responsiveness to protein-tyrosine kinases and v-Ras (B. Bell and I. Sadowski, Oncogene 13:2687-2697, 1996). Here we demonstrate that representative MFNLPs from two patients specifically bind RBF-2. In both cases, deletion of the MFNLP caused elevated LTR-directed transcription in cells expressing RBF-2 but not in cells with undetectable RBF-2. RBF-1, but not RBF-2, appears to contain the Ets transcription factor family member GABPalpha/GABPbeta1. Taken together with the fact that every MFNLP from a comparative stud...Continue Reading

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Citations

Jun 25, 2002·AIDS Research and Human Retroviruses·Caterina SerraAntonina Dolei
Dec 9, 2004·AIDS Research and Human Retroviruses·Karen F T CopelandJohn E Kim
Jan 3, 2006·AIDS Research and Human Retroviruses·Eva Ramírez De ArellanoAfrica Holguín
Sep 10, 2003·Journal of Leukocyte Biology·Olivier RohrEvelyne Schaeffer
Jan 26, 2002·Journal of Biomedical Science·Esther LengIvan Sadowski
Dec 14, 2021·Frontiers in Microbiology·Disha BhangeUdaykumar Ranga

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