PMID: 8940738Nov 1, 1996Paper

Naturally occurring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients

Pediatric Hematology and Oncology
R ErttmannC W Vogel

Abstract

A novel cytotoxic mechanism against neuroblastoma (NB) cells based on natural immunoglobulin M serum antibodies is described. The occurrence of these antibodies, which are able to induce complement-mediated cytolysis of NB cells, has been investigated in several age groups of healthy persons and in patients with NB. The cytotoxicity of serum samples has been measured in terms of propidium iodide DNA incorporation using a FACScan. The prevalence of anti-NB 1gM antibodies shows a strong age dependence characterized by a nearly complete lack in the first year of life and a steep rise up to 82% beginning with the second year of life. In the sera of 11 NB-bearing patients no cytotoxicity has been found, despite the fact that 8 of these patients were older than 1 year. These findings lead to the hypothesis that natural 1gM antibodies could play a role as an immunological control mechanism against NB.

References

Jul 1, 1995·Medical and Pediatric Oncology·M N Beck, D Beck
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·M W OllertC W Vogel

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Citations

Sep 10, 2003·Analytical Biochemistry·Edzard SpillnerReinhard Bredehorst
Mar 28, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M W OllertC W Vogel
Jun 19, 2008·Autoimmunity Reviews·Rudolf Erttmann
Sep 27, 2006·Cancer Science·André S BachmannCarl-Wilhelm Vogel

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