Naturally occurring IgM anti-leukocyte autoantibodies (IgM-ALA) inhibit T cell activation and chemotaxis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Peter I LoboChristopher Burtner

Abstract

The physiological relevance of naturally occurring IgM-ALA remains to be elucidated. These autoantibodies are present from birth and increase in diverse inflammatory states that are both infectious and noninfectious. Clinical observations showing significantly less acute allograft rejections in recipients having high IgM-ALA levels, led us to investigate whether IgM-ALA could have a functional role in attenuating T cell mediated inflammatory responses. In pursuit of this hypothesis, we did studies using IgM purified from the serum of normal individuals, patients with end stage renal disease, and HIV-1 infection. All preparations of IgM immunoprecipitated certain receptors e.g., CD3, CD4, CCR5, and CXCR4 from whole cell lysates but failed to immunoprecipitate IL-2R and HLA Ags. In physiological doses IgM down-regulated CD4, CD2 and CD86 but not CD8 and CD28, inhibited T cell proliferation, decreased production of certain proinflammatory cytokines e.g., TNF-alpha, IL-13 and IL-2, but not IFN- gamma, IL-1beta, GM-CSF, IL-6 and IL-8 and inhibited leukocyte chemotaxis. These inhibitory effects were more pronounced when using IgM from patients with high levels of IgM-ALA and these inhibitory effects were significantly reduced after u...Continue Reading

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Citations

Apr 20, 2010·Journal of Clinical Immunology·Peter I LoboHong Pei
Dec 9, 2016·Journal of the American Heart Association·Hamid HosseiniTin Kyaw
Jul 22, 2018·International Journal of Molecular Sciences·Ana Esteve-SoléLaia Alsina
Jun 25, 2018·Journal of the American Heart Association·Hamid HosseiniTin Kyaw
Feb 8, 2019·Frontiers in Immunology·Thevani PillayDerseree Archary
Jan 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter I LoboMark D Okusa
Jan 21, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhito HonjoHiromi Kubagawa
Jan 23, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jia-Jun LiaoEdward J Goetzl
Nov 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manuela ColucciMarina Vivarelli
Dec 9, 2008·Trends in Immunology·Hans U LutzSrini Kaveri

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