Naturally occurring MHR variants in Turkish patients infected with hepatitis B virus

Journal of Medical Virology
A Arzu SayinerAylin Sengonul

Abstract

Major B-cell epitopes are located at the major hydrophilic region (MHR) of hepatitis B virus (HBV) surface antigen (HBsAg). The genotypes, subtypes, and naturally occurring amino acid (aa) substitutions of MHR were analyzed in 81 Turkish adult patients (41 inactive HBsAg carriers and 40 patients with chronic hepatitis B) by direct sequencing of the S gene fragment. All the isolates were genotype D according to the phylogenetic analysis. The most common HBsAg subtype was ayw2, followed by ayw3 while one isolate specified ayw4 by encoding Leu127. MHR variants were detected in 22 of the 81 (27.2%) isolates. The prevalence was significantly higher in the chronic hepatitis B group (42.5%) compared to inactive HBsAg carriers (12.2%). Twenty-two samples had a total of 26 amino acid substitutions involving 14 positions. The majority of the patients had a single variation. Most of the amino acid substitutions were located at the HBs1 region of the MHR, while 9 of the 26 were in the classic "a" determinant (aa 124-147). When samples with "a" variants were evaluated by two different commercial HBsAg tests, only the isolate with Ser143Leu variation had a decreased reactivity in the assay using monoclonal antibodies for capture and detectio...Continue Reading

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Citations

Jun 23, 2009·Epidemiology and Infection·N AntakiUNKNOWN Syrian Working Group for the Study of Viral Hepatitis
Nov 10, 2010·PLoS Pathogens·Hung-Cheng LiChiaho Shih
Jun 7, 2011·The Journal of Infection·Bouchra KitabSoumaya Benjelloun
Jun 17, 2011·Journal of Medical Virology·Laura E CoxJean-Pierre Allain
Oct 24, 2013·Journal of Medical Virology·Mahmoud Reza PourkarimMarc Van Ranst
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Dec 3, 2015·Journal of Medical Virology·Gadissa Bedada HundieBart L Haagmans
Apr 9, 2016·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Walaa M Abu ZeidMohamed A Shemis
Apr 8, 2015·World Journal of Hepatology·Yoshihiko YanoYoshitake Hayashi
Oct 22, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ahmed A Al-QahtaniMohammed N Al-Ahdal

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