Naturally Occurring Nervonic Acid Ester Improves Myelin Synthesis by Human Oligodendrocytes

Cells
Natalia LewkowiczPrzemysław Lewkowicz

Abstract

The dysfunction of oligodendrocytes (OLs) is regarded as one of the major causes of inefficient remyelination in multiple sclerosis, resulting gradually in disease progression. Oligodendrocytes are derived from oligodendrocyte progenitor cells (OPCs), which populate the adult central nervous system, but their physiological capability to myelin synthesis is limited. The low intake of essential lipids for sphingomyelin synthesis in the human diet may account for increased demyelination and the reduced efficiency of the remyelination process. In our study on lipid profiling in an experimental autoimmune encephalomyelitis brain, we revealed that during acute inflammation, nervonic acid synthesis is silenced, which is the effect of shifting the lipid metabolism pathway of common substrates into proinflammatory arachidonic acid production. In the experiments on the human model of maturating oligodendrocyte precursor cells (hOPCs) in vitro, we demonstrated that fish oil mixture (FOM) affected the function of hOPCs, resulting in the improved synthesis of myelin basic protein, myelin oligodendrocyte glycoprotein, and proteolipid protein, as well as sphingomyelin. Additionally, FOM reduces proinflammatory cytokines and chemokines, and en...Continue Reading

References

Jan 1, 1979·Annals of Neurology·J W Prineas, F Connell
Nov 2, 1974·Lancet·B W Agranoff, D Goldberg
Dec 1, 1998·Journal of Neurochemistry·M Martínez, I Mougan
Jul 12, 2002·Journal of Neuroscience Research·Yangzhou Du, Cheryl F Dreyfus
Mar 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Stefan Schwarz, Hans Leweling
Aug 16, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Bianca Weinstock-GuttmanRichard Rudick
Mar 11, 2006·Neuroscience·E KawakitaO Shido
Jun 15, 2007·Biochimica Et Biophysica Acta·Katherine A Burns, John P Vanden Heuvel
Oct 18, 2007·Journal of Neuroscience Research·Serafina SalvatiLuigi Vitelli
Jun 23, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hau D LeMark Puder
Jul 9, 2009·Physiological Reviews·Gregory R Steinberg, Bruce E Kemp
Sep 22, 2010·Brain : a Journal of Neurology·Stephan BramowHenning Laursen
Jun 16, 2011·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Alden A DimaAnne L Plant
Nov 1, 2012·Science·Steven A GoldmanMartha S Windrem
Apr 9, 2013·The Biochemical Journal·Woojin Scott KimGlenda M Halliday
Jul 23, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E NtoumaniK-G Sabel
Apr 23, 2014·Biomolecules & Therapeutics·Takayuki Sassa, Akio Kihara
Jul 23, 2014·Acta Neuropathologica Communications·Francesco GirolamoMaria Trojano
Dec 17, 2014·Scientific Reports·Songela ChenXiaoming Hu
Feb 20, 2015·ASN Neuro·Paolo Riccio, Rocco Rossano
Mar 27, 2016·Experimental Neurology·Yangyang Huang, Cheryl F Dreyfus
Jul 16, 2016·Journal of Neurochemistry·Juan Pablo PalaviciniXianlin Han
Jan 25, 2017·BMC Neuroscience·Elise SiegertKarsten H Weylandt
Feb 16, 2017·Neural Regeneration Research·Filip Petković, Bernardo Castellano
Oct 19, 2017·The International Journal of Neuropsychopharmacology·Yuki KageyamaTadafumi Kato
Nov 17, 2017·Nature Reviews. Neuroscience·Robin J M Franklin, Charles Ffrench-Constant
Feb 27, 2018·Applied Microbiology and Biotechnology·Yong FanFu-Li Li

❮ Previous
Next ❯

Citations

Feb 13, 2020·Journal of Clinical Medicine·Davide MarangonMarta Fumagalli
Jun 13, 2020·Immunometabolism·Colleen E Hayes, James M Ntambi
Nov 20, 2020·International Journal of Molecular Sciences·Lucas M O'NeillJames M Ntambi
Jan 29, 2020·Advanced Drug Delivery Reviews·Jeroen F J BogieJerome J A Hendriks
Jun 1, 2021·Translational Neuroscience·Dandong HuJi Zhang
Jul 3, 2021·International Journal of Environmental Research and Public Health·Dariusz KotlęgaMałgorzata Szczuko

❮ Previous
Next ❯

Methods Mentioned

BETA
PMA
Assay
PCR

Software Mentioned

EZ
Agilent 2100

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.