Naturally occurring neuronal death during the development of the inferior olive in the chick

Neuroscience Research
A. López-Román, J A Armengol

Abstract

Naturally occurring neuronal death was found by in situ labelling of nuclear DNA fragmentation during the development of the chick inferior olive. Counting neuronal perikarya showed an evident loss of cells from embryonic day 18 to hatching. This reduction in neuronal numbers was followed by an increase of similar size from days 1-4 post-hatching. This biphasic evolution of the neuronal numbers is quite similar to that found in the inferior olive of rodents during the first two weeks of the postnatal life, a period also characterized by definitive synaptogenesis between climbing fibers and Pukinje cells in the cerebellum of the rodents. The similarity in the evolution of neuronal number in the inferior olive of both rodents and chicks, seems to indicate that definitive synaptogenesis between climbing fibers and Purkinje cells might occur from embryonic day 18 to postnatal day 3 in the chick cerebellum. Nevertheless, during the phase of cell loss the climbing fibers of chick have attained a more mature developmental stage than those of the rat. This difference suggests that naturally occurring neuronal death may be independent of the elimination of redundant axonic collaterals during the definitive climbing fibers-Purkinje cell ...Continue Reading

References

Oct 11, 1979·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K W Caddy, T J Biscoe
Sep 15, 1977·The Journal of Comparative Neurology·S L FreedmanG J Vielvoye
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jul 1, 1990·The Journal of Comparative Neurology·C A MasonS M Catalano
Aug 1, 1974·Journal of Neurocytology·R F Foelix, R Oppenheim
Jul 1, 1971·The Journal of Comparative Neurology·J L O'LearyJ M Smith
Jan 1, 1983·Brain, Behavior and Evolution·S E Furber
May 10, 1984·The Journal of Comparative Neurology·S E Furber
Oct 1, 1980·Journal of Neurocytology·D L GiordanoT J Cunningham
Jun 1, 1995·Archives of Histology and Cytology·A C LoR W Oppenheim
Jul 14, 1995·Brain Research. Developmental Brain Research·Y FuhrmanN Delhaye-Bouchaud
May 1, 1996·Neuroscience Research·A López-Ramán, J A Armengol
Oct 1, 1954·The Journal of Comparative Neurology·L VOGT-NILSEN
Jan 1, 1951·Journal of Morphology·V HAMBURGER, H L HAMILTON

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Citations

Aug 23, 2005·Brain Research. Brain Research Reviews·Silvia H MadalossoJosé A Armengol
Jan 7, 2006·The Journal of Veterinary Medical Science·Reda RashedMasato Uehara
Apr 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Detlev GrabsMathias Bergmann

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