Naturally occurring PDGF receptor inhibitors with potential anti-atherosclerotic properties

Vascular Pharmacology
Chiara Ricci, Nicola Ferri

Abstract

Platelet-derived growth factor (PDGF) represents one of the most prominent inducer of smooth muscle cell (SMC) migration and proliferation. Homo- and heterodimers of PDGF-A, PDGF-B, PDGF-C and PDGF-D subunits act by binding to homo- or heterodimers of the PDGF tyrosine kinase receptors, PDGFR-α and PDGFR-β. The essential role of PDGFR signaling on restenosis post-angioplasty or atherosclerosis has been demonstrated by using blocking antibodies to PDGF or the tyrosine kinase inhibitor imatinib. More specifically, molecular studies have defined the intracellular signaling pathways activated by PDGF, inducing the cell cycle progression and the migration of SMCs. Considering the relevant role of PDGF in atherogenesis, several studies have been performed to investigate the effect of naturally occurring compounds on both in vitro and in vivo experimental models of atherogenesis. The present review will briefly summarize the pathophysiological role of PDGF and the studies of natural inhibitors tested in in vivo experimental models of restenosis in response to vascular injury and/or atherosclerosis.

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Citations

Jan 27, 2017·Reproductive Sciences·Arianna VigniniAndrea Ciavattini
Apr 26, 2017·European Journal of Preventive Cardiology·Emese Tóth-ZsámbokiRóbert G Kiss
May 4, 2017·Journal of Cellular Physiology·Liu OuyangHui Huang
Jul 13, 2017·Journal of Cellular and Molecular Medicine·Tzu-Ming WangSuh-Hang H Juo
May 9, 2019·Stem Cells International·Changming XieHui Huang
Dec 30, 2020·International Journal of Molecular Sciences·Lei Wang, Chaojun Tang
Jul 9, 2021·The Journal of Experimental Medicine·Yu-Wen ChengPing-Jin Gao
Feb 8, 2018·Molecular Aspects of Medicine·Erika FolestadDick Wågsäter

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