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Naturally Occurring Sclareol Diterpene Augments the Chemosensitivity of Human Hela Cervical Cancer Cells by Inducing Mitochondrial Mediated Programmed Cell Death, S-Phase Cell Cycle Arrest and Targeting Mitogen-Activated Protein Kinase (MAPK)/Extracellular-Signal-Regulated Kinase (ERK) Signaling Pathway

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Jan 15, 2020

Wang LiZhu Zhongxiang

Abstract

BACKGROUND Cervical cancer is a major threat to female health worldwide. This study was performed to study the anticancer potential of sclareol and as a chemo-sensitizing agent against human cervical cancer cells along with evaluating its effects on apoptosis, cell cycle arrest, and MAP...read more

Mentioned in this Paper

Cdc25C protein
MAPK Signaling Pathway
Bax protein
Chemicals
Evaluation
Nuclear Fragmentation Involved in Apoptotic Nuclear Change
ELP5 gene
Cyclin-Dependent Kinases
Microscopy, Phase-Contrast
Mitochondria
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Naturally Occurring Sclareol Diterpene Augments the Chemosensitivity of Human Hela Cervical Cancer Cells by Inducing Mitochondrial Mediated Programmed Cell Death, S-Phase Cell Cycle Arrest and Targeting Mitogen-Activated Protein Kinase (MAPK)/Extracellular-Signal-Regulated Kinase (ERK) Signaling Pathway

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

Jan 15, 2020

Wang LiZhu Zhongxiang

PMID: 31935210

DOI: 10.12659/msm.920248

Abstract

BACKGROUND Cervical cancer is a major threat to female health worldwide. This study was performed to study the anticancer potential of sclareol and as a chemo-sensitizing agent against human cervical cancer cells along with evaluating its effects on apoptosis, cell cycle arrest, and MAP...read more

Mentioned in this Paper

Cdc25C protein
MAPK Signaling Pathway
Bax protein
Chemicals
Evaluation
Nuclear Fragmentation Involved in Apoptotic Nuclear Change
ELP5 gene
Cyclin-Dependent Kinases
Microscopy, Phase-Contrast
Mitochondria

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