Naturally Occurring tRNAs With Non-canonical Structures

Frontiers in Microbiology
Natalie KrahnDieter Söll

Abstract

Transfer RNA (tRNA) is the central molecule in genetically encoded protein synthesis. Most tRNA species were found to be very similar in structure: the well-known cloverleaf secondary structure and L-shaped tertiary structure. Furthermore, the length of the acceptor arm, T-arm, and anticodon arm were found to be closely conserved. Later research discovered naturally occurring, active tRNAs that did not fit the established 'canonical' tRNA structure. This review discusses the non-canonical structures of some well-characterized natural tRNA species and describes how these structures relate to their role in translation. Additionally, we highlight some newly discovered tRNAs in which the structure-function relationship is not yet fully understood.

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Methods Mentioned

BETA
Aminoacylation
aminoacylates

Related Concepts

Research
RNA
Transfer RNA
Protein Biosynthesis
Structure
Gene Mutant
RNA, Untranslated
Species
FDXACB1 gene

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