Nature-derived microbiota exposure as a novel immunomodulatory approach

Future Microbiology
Noora NurminenAki Sinkkonen

Abstract

Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. The method was safe and feasible; exposure was associated with an increase in gut microbial diversity. If these findings are reproduced in larger studies nature-derived microbial exposure strategies could be further developed for testing their efficacy in the treatment and prevention of immune-mediated diseases.

References

Jul 6, 2006·Applied and Environmental Microbiology·T Z DeSantisG L Andersen
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Nov 14, 2008·Nucleic Acids Research·J R ColeJ M Tiedje
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jun 28, 2011·Bioinformatics·Robert C EdgarRob Knight
May 15, 2013·The World Allergy Organization Journal·Tari HaahtelaUNKNOWN WAO Special Committee on Climate Change and Biodiversity
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Apr 24, 2015·Annals of Medicine·Leena von HertzenWillem M de Vos
Jan 28, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sarah L BridgmanMeghan B Azad
Feb 2, 2016·Nature Medicine·Maria G Dominguez-BelloJose C Clemente
Dec 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Katharine Z CoyteWilliam M Durham
Mar 21, 2017·Digestive Diseases and Sciences·Nathaniel Aviv Cohen, Nitsan Maharshak

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Citations

Aug 21, 2019·International Journal of Environmental Research and Public Health·Riikka PuhakkaUNKNOWN ADELE Research Group
Apr 11, 2019·Frontiers in Microbiology·Nan HuiUNKNOWN ADELE Research Group
Sep 20, 2020·International Journal of Environmental Research and Public Health·Kati PitkänenRiikka Puhakka
Feb 6, 2020·The Science of the Total Environment·Anirudra ParajuliUNKNOWN ADELE study group (all additional members of the ADELE study group in Lahti and Tampere)
Mar 9, 2021·The Science of the Total Environment·Joel E BrameMartin F Breed
Apr 11, 2021·Applied Microbiology and Biotechnology·Viia Kõiv, Tanel Tenson
May 1, 2021·International Journal of Environmental Research and Public Health·Mika Saarenpää The Adele Research Group
Jul 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying ZhuYue Zeng
May 7, 2021·Diabetes Care·Noora NurminenHeikki Hyöty
Aug 18, 2021·Environment International·Marja I RoslundUNKNOWN ADELE research group
Dec 8, 2021·Immunity, Inflammation and Disease·Martín Ignacio González-RodríguezUNKNOWN ADELE Research Group

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Datasets Mentioned

BETA
PRJNA390051

Methods Mentioned

BETA
amplicon sequencing

Clinical Trials Mentioned

NCT03351543

Software Mentioned

Mothur
QIIME
SPSS
UCHIME
phyloseq
QQ
vegan
- Plot
SILVA
ggplot2

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