Nature engineered diatom biosilica as drug delivery systems

Journal of Controlled Release : Official Journal of the Controlled Release Society
U T UthappaMahaveer D Kurkuri

Abstract

Diatoms, unicellular photosynthetic algae covered with siliceous cell wall, are also called frustule. These are the most potential naturally available materials for the development of cost-effective drug delivery systems because of their excellent biocompatibility, high surface area, low cost and ease of surface modification. Mesoporous silica materials such as MCM-41 and SBA-15 have been extensively used in drug delivery area. Their synthesis is challenging, time consuming, requires toxic chemicals and are energy intensive, making the entire process expensive and non-viable. Therefore, it is necessary to explore alternative materials. Surprisingly, nature has provided some exciting materials called diatoms; biosilica is one such a material that can be potentially used as a drug delivery vehicle. The present review focuses on different types of diatom species used in drug delivery with respect to their structural properties, morphology, purification process and surface functionalization. In this review, recent advances along with their limitations as well as the future scope to develop them as potential drug delivery vehicles are discussed.

Citations

Jun 11, 2020·Materials·Weronika BrzozowskaBogusław Buszewski
Nov 23, 2018·Pharmaceutics·Monica TerraccianoIlaria Rea
Oct 18, 2019·Pharmaceutics·Joachim Delasoie, Fabio Zobi
May 24, 2019·Applied Biochemistry and Biotechnology·Sarah Mousa AsiriAyhan Bozkurt
Apr 20, 2020·Photodiagnosis and Photodynamic Therapy·Javid EsfandyariHossein Naderi-Manesh
Dec 11, 2020·Expert Opinion on Drug Delivery·Jiani DongQubo Zhu
Feb 20, 2021·Environmental Pollution·Rajesh K SrivastavaTejraj M Aminabhavi
Feb 18, 2021·The New Phytologist·Luisana AvilanBrigitte Gontero
Jun 25, 2020·Advances in Colloid and Interface Science·Ganesan SriramMahaveer D Kurkuri
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Sarah BriceñoGema González
May 8, 2021·Frontiers in Chemistry·Kumar Sachin, Santosh Kumar Karn
Sep 10, 2021·ACS Biomaterials Science & Engineering·Shrinath BhatMahaveer D Kurkuri
Oct 5, 2021·Chemical Society Reviews·Qi-Wen ChenXian-Zheng Zhang

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